Abstract
Objective
Current procedure at our centre for partitioning multi-dose vials of 18F-FDG utilises a manual method. In order to reduce extremity dose while reducing contamination risk, maintaining product sterility and also improving accuracy of injected activity, we recently purchased a new semi-automated partitioning system (μDDS-A, TEMA Sinergie, Faenza, Italy). This work reports on the operating characteristics of the system and its validation for clinical use in terms of dispensing accuracy and extremity dose reduction.
Methods
A range of operators carried out 300 automated partitioning procedures by following a typical working day setup. Accuracy of the activity resulting from system partitioning compared to true syringe activity was determined. We also determined the precision of system-determined activity compared to user requested activity. Cumulated finger dose for automated and manual partitioning techniques was measured at the fingertip by a digital dosimeter, recording the dose at different stages of the procedure.
Results
Comparisons made between the final syringe activity measured by the system and the measurement of the true syringe activity independently of the system was within ±5 % for 96.63% of syringes. Precision of the syringe activity provided by the system to the user-requested activity was within ±10 % for 96.96% of measurements. Average finger doses compared to a manual partitioning method showed a reduction of up to 80% when relying only on the system measurement of activity.
Conclusion
The μDDS-A reproducibly partitions a vial of 18F-FDG, and offers a significant reduction in extremity dose to the operator of up to 80% in comparison to a manual partition technique.
Current procedure at our centre for partitioning multi-dose vials of 18F-FDG utilises a manual method. In order to reduce extremity dose while reducing contamination risk, maintaining product sterility and also improving accuracy of injected activity, we recently purchased a new semi-automated partitioning system (μDDS-A, TEMA Sinergie, Faenza, Italy). This work reports on the operating characteristics of the system and its validation for clinical use in terms of dispensing accuracy and extremity dose reduction.
Methods
A range of operators carried out 300 automated partitioning procedures by following a typical working day setup. Accuracy of the activity resulting from system partitioning compared to true syringe activity was determined. We also determined the precision of system-determined activity compared to user requested activity. Cumulated finger dose for automated and manual partitioning techniques was measured at the fingertip by a digital dosimeter, recording the dose at different stages of the procedure.
Results
Comparisons made between the final syringe activity measured by the system and the measurement of the true syringe activity independently of the system was within ±5 % for 96.63% of syringes. Precision of the syringe activity provided by the system to the user-requested activity was within ±10 % for 96.96% of measurements. Average finger doses compared to a manual partitioning method showed a reduction of up to 80% when relying only on the system measurement of activity.
Conclusion
The μDDS-A reproducibly partitions a vial of 18F-FDG, and offers a significant reduction in extremity dose to the operator of up to 80% in comparison to a manual partition technique.
Original language | English |
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Article number | 1011R1 |
Pages (from-to) | 151-159 |
Journal | Nuclear Medicine Communications |
Volume | 35 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2014 |