Validation of non-rigid registration using finite element methods

M F Insana, R M Leahy (Editor), A D Castellano Smith, M O Leach, C Hayes, A Degenhard, R Hose, D L G Hill, D J Hawkes

Research output: Chapter in Book/Report/Conference proceedingConference paper

39 Citations (Scopus)


We present a novel validation method for non-rigid registration using a simulation of deformations based on biomechanical modelling of tissue properties. This method is tested on a previously-developed (D. Rueckert et al., 1999) non-rigid registration method for dynamic contrast-enhanced magnetic resonance (MR) mammography image pairs. We have constructed finite-element breast models and applied a range of displacements to them, with an emphasis on generating physically plausible deformations which may occur during normal patient scanning procedures. From the finite element method (FEM) solutions, we have generated a set of deformed contrast-enhanced images, against which we have registered the original dynamic image pairs. The registration results have been successfully validated at all breast tissue locations by comparing the recovered displacements with the biomechanical displacements. The validation method presented in this paper is an important tool to provide biomechanical gold-standard deformations for registration error quantification, which may also form the basis to improve and compare different non-rigid registration techniques for a diversity of medical applications. (26 References).
Original languageEnglish
Title of host publicationConference Proceedings - Lecture Notes in Computer Science (LNCS) Vol#2082
Place of PublicationBerlin, Germany
Pages344 - 357
Number of pages14
Publication statusPublished - 2001
EventIPMI 2001: Information Processing in Medical Imaging - 17th International Conference - DAVIS, CALIFORNIA
Duration: 18 Jun 200122 Jun 2001


ConferenceIPMI 2001: Information Processing in Medical Imaging - 17th International Conference


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