King's College London

Research portal

Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): I. Psychosis superspectrum

Research output: Contribution to journalArticle

Standard

Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP) : I. Psychosis superspectrum. / HiTOP Utility Workgroup.

In: World Psychiatry, Vol. 19, No. 2, 01.06.2020, p. 151-172.

Research output: Contribution to journalArticle

Harvard

HiTOP Utility Workgroup 2020, 'Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): I. Psychosis superspectrum', World Psychiatry, vol. 19, no. 2, pp. 151-172. https://doi.org/10.1002/wps.20730

APA

HiTOP Utility Workgroup (2020). Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): I. Psychosis superspectrum. World Psychiatry, 19(2), 151-172. https://doi.org/10.1002/wps.20730

Vancouver

HiTOP Utility Workgroup. Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): I. Psychosis superspectrum. World Psychiatry. 2020 Jun 1;19(2):151-172. https://doi.org/10.1002/wps.20730

Author

HiTOP Utility Workgroup. / Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP) : I. Psychosis superspectrum. In: World Psychiatry. 2020 ; Vol. 19, No. 2. pp. 151-172.

Bibtex Download

@article{4f15f3048e02472db2fade18adfaffef,
title = "Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): I. Psychosis superspectrum",
abstract = "The Hierarchical Taxonomy of Psychopathology (HiTOP) is a scientific effort to address shortcomings of traditional mental disorder diagnoses, which suffer from arbitrary boundaries between psychopathology and normality, frequent disorder co-occurrence, heterogeneity within disorders, and diagnostic instability. This paper synthesizes evidence on the validity and utility of the thought disorder and detachment spectra of HiTOP. These spectra are composed of symptoms and maladaptive traits currently subsumed within schizophrenia, other psychotic disorders, and schizotypal, paranoid and schizoid personality disorders. Thought disorder ranges from normal reality testing, to maladaptive trait psychoticism, to hallucinations and delusions. Detachment ranges from introversion, to maladaptive detachment, to blunted affect and avolition. Extensive evidence supports the validity of thought disorder and detachment spectra, as each spectrum reflects common genetics, environmental risk factors, childhood antecedents, cognitive abnormalities, neural alterations, biomarkers, and treatment response. Some of these characteristics are specific to one spectrum and others are shared, suggesting the existence of an overarching psychosis superspectrum. Further research is needed to extend this model, such as clarifying whether mania and dissociation belong to thought disorder, and explicating processes that drive development of the spectra and their subdimensions. Compared to traditional diagnoses, the thought disorder and detachment spectra demonstrated substantially improved utility: greater reliability, larger explanatory and predictive power, and higher acceptability to clinicians. Validated measures are available to implement the system in practice. The more informative, reliable and valid characterization of psychosis-related psychopathology offered by HiTOP can make diagnosis more useful for research and clinical care.",
keywords = "clinical utility, detachment, HiTOP, in­troversion, personality disorders, psychosis, psychotic disorders, psychoticism, schizophrenia, thought disorder",
author = "{HiTOP Utility Workgroup} and Roman Kotov and Jonas, {Katherine G.} and Carpenter, {William T.} and Dretsch, {Michael N.} and Eaton, {Nicholas R.} and Forbes, {Miriam K.} and Forbush, {Kelsie T.} and Kelsey Hobbs and Ulrich Reininghaus and Tim Slade and South, {Susan C.} and Matthew Sunderland and Waszczuk, {Monika A.} and Widiger, {Thomas A.} and Wright, {Aidan G C.} and Zald, {David H.} and Krueger, {Robert F.} and David Watson",
year = "2020",
month = jun,
day = "1",
doi = "10.1002/wps.20730",
language = "English",
volume = "19",
pages = "151--172",
journal = "World Psychiatry",
issn = "1723-8617",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP)

T2 - I. Psychosis superspectrum

AU - HiTOP Utility Workgroup

AU - Kotov, Roman

AU - Jonas, Katherine G.

AU - Carpenter, William T.

AU - Dretsch, Michael N.

AU - Eaton, Nicholas R.

AU - Forbes, Miriam K.

AU - Forbush, Kelsie T.

AU - Hobbs, Kelsey

AU - Reininghaus, Ulrich

AU - Slade, Tim

AU - South, Susan C.

AU - Sunderland, Matthew

AU - Waszczuk, Monika A.

AU - Widiger, Thomas A.

AU - Wright, Aidan G C.

AU - Zald, David H.

AU - Krueger, Robert F.

AU - Watson, David

PY - 2020/6/1

Y1 - 2020/6/1

N2 - The Hierarchical Taxonomy of Psychopathology (HiTOP) is a scientific effort to address shortcomings of traditional mental disorder diagnoses, which suffer from arbitrary boundaries between psychopathology and normality, frequent disorder co-occurrence, heterogeneity within disorders, and diagnostic instability. This paper synthesizes evidence on the validity and utility of the thought disorder and detachment spectra of HiTOP. These spectra are composed of symptoms and maladaptive traits currently subsumed within schizophrenia, other psychotic disorders, and schizotypal, paranoid and schizoid personality disorders. Thought disorder ranges from normal reality testing, to maladaptive trait psychoticism, to hallucinations and delusions. Detachment ranges from introversion, to maladaptive detachment, to blunted affect and avolition. Extensive evidence supports the validity of thought disorder and detachment spectra, as each spectrum reflects common genetics, environmental risk factors, childhood antecedents, cognitive abnormalities, neural alterations, biomarkers, and treatment response. Some of these characteristics are specific to one spectrum and others are shared, suggesting the existence of an overarching psychosis superspectrum. Further research is needed to extend this model, such as clarifying whether mania and dissociation belong to thought disorder, and explicating processes that drive development of the spectra and their subdimensions. Compared to traditional diagnoses, the thought disorder and detachment spectra demonstrated substantially improved utility: greater reliability, larger explanatory and predictive power, and higher acceptability to clinicians. Validated measures are available to implement the system in practice. The more informative, reliable and valid characterization of psychosis-related psychopathology offered by HiTOP can make diagnosis more useful for research and clinical care.

AB - The Hierarchical Taxonomy of Psychopathology (HiTOP) is a scientific effort to address shortcomings of traditional mental disorder diagnoses, which suffer from arbitrary boundaries between psychopathology and normality, frequent disorder co-occurrence, heterogeneity within disorders, and diagnostic instability. This paper synthesizes evidence on the validity and utility of the thought disorder and detachment spectra of HiTOP. These spectra are composed of symptoms and maladaptive traits currently subsumed within schizophrenia, other psychotic disorders, and schizotypal, paranoid and schizoid personality disorders. Thought disorder ranges from normal reality testing, to maladaptive trait psychoticism, to hallucinations and delusions. Detachment ranges from introversion, to maladaptive detachment, to blunted affect and avolition. Extensive evidence supports the validity of thought disorder and detachment spectra, as each spectrum reflects common genetics, environmental risk factors, childhood antecedents, cognitive abnormalities, neural alterations, biomarkers, and treatment response. Some of these characteristics are specific to one spectrum and others are shared, suggesting the existence of an overarching psychosis superspectrum. Further research is needed to extend this model, such as clarifying whether mania and dissociation belong to thought disorder, and explicating processes that drive development of the spectra and their subdimensions. Compared to traditional diagnoses, the thought disorder and detachment spectra demonstrated substantially improved utility: greater reliability, larger explanatory and predictive power, and higher acceptability to clinicians. Validated measures are available to implement the system in practice. The more informative, reliable and valid characterization of psychosis-related psychopathology offered by HiTOP can make diagnosis more useful for research and clinical care.

KW - clinical utility

KW - detachment

KW - HiTOP

KW - in­troversion

KW - personality disorders

KW - psychosis

KW - psychotic disorders

KW - psychoticism

KW - schizophrenia

KW - thought disorder

UR - http://www.scopus.com/inward/record.url?scp=85084479932&partnerID=8YFLogxK

U2 - 10.1002/wps.20730

DO - 10.1002/wps.20730

M3 - Article

AN - SCOPUS:85084479932

VL - 19

SP - 151

EP - 172

JO - World Psychiatry

JF - World Psychiatry

SN - 1723-8617

IS - 2

ER -

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454