Vascular growth factors play critical roles in kidney glomeruli

Luigi Gnudi; Sara Benedetti; Adrian S. Woolf; David A. Long

doi:10.1042/CS20150403

Vascular growth factors play critical roles in kidney glomeruli

Luigi Gnudi^*, Sara Benedetti, Adrian S. Woolf, David A. Long

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

43 Citations (Scopus)

Abstract

Kidney glomeruli ultrafilter blood to generate urine and they are dysfunctional in a variety of kidney diseases. There are two key vascular growth factor families implicated in glomerular biology and function, namely the vascular endothelial growth factors (VEGFs) and the angiopoietins (Angpt). We present examples showing not only how these molecules help generate and maintain healthy glomeruli but also how they drive disease when their expression is dysregulated. Finally, we review how manipulating VEGF and Angpt signalling may be used to treat glomerular disease.

Original language	English
Pages (from-to)	1225-1236
Number of pages	12
Journal	Clinical Science
Volume	129
Issue number	12
DOIs	https://doi.org/10.1042/CS20150403
Publication status	Published - 11 Nov 2015

Keywords

Angiopoietins
Endothelial cells
Glomerulus
Permeability
Podocytes
Vascular endothelial growth factor (VEGF)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1042/CS20150403

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title = "Vascular growth factors play critical roles in kidney glomeruli",

abstract = "Kidney glomeruli ultrafilter blood to generate urine and they are dysfunctional in a variety of kidney diseases. There are two key vascular growth factor families implicated in glomerular biology and function, namely the vascular endothelial growth factors (VEGFs) and the angiopoietins (Angpt). We present examples showing not only how these molecules help generate and maintain healthy glomeruli but also how they drive disease when their expression is dysregulated. Finally, we review how manipulating VEGF and Angpt signalling may be used to treat glomerular disease.",

keywords = "Angiopoietins, Endothelial cells, Glomerulus, Permeability, Podocytes, Vascular endothelial growth factor (VEGF)",

author = "Luigi Gnudi and Sara Benedetti and Woolf, {Adrian S.} and Long, {David A.}",

year = "2015",

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doi = "10.1042/CS20150403",

language = "English",

volume = "129",

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TY - JOUR

T1 - Vascular growth factors play critical roles in kidney glomeruli

AU - Gnudi, Luigi

AU - Benedetti, Sara

AU - Woolf, Adrian S.

AU - Long, David A.

PY - 2015/11/11

Y1 - 2015/11/11

N2 - Kidney glomeruli ultrafilter blood to generate urine and they are dysfunctional in a variety of kidney diseases. There are two key vascular growth factor families implicated in glomerular biology and function, namely the vascular endothelial growth factors (VEGFs) and the angiopoietins (Angpt). We present examples showing not only how these molecules help generate and maintain healthy glomeruli but also how they drive disease when their expression is dysregulated. Finally, we review how manipulating VEGF and Angpt signalling may be used to treat glomerular disease.

AB - Kidney glomeruli ultrafilter blood to generate urine and they are dysfunctional in a variety of kidney diseases. There are two key vascular growth factor families implicated in glomerular biology and function, namely the vascular endothelial growth factors (VEGFs) and the angiopoietins (Angpt). We present examples showing not only how these molecules help generate and maintain healthy glomeruli but also how they drive disease when their expression is dysregulated. Finally, we review how manipulating VEGF and Angpt signalling may be used to treat glomerular disease.

KW - Angiopoietins

KW - Endothelial cells

KW - Glomerulus

KW - Permeability

KW - Podocytes

KW - Vascular endothelial growth factor (VEGF)

UR - http://www.scopus.com/inward/record.url?scp=84952039692&partnerID=8YFLogxK

U2 - 10.1042/CS20150403

DO - 10.1042/CS20150403

M3 - Review article

C2 - 26561594

AN - SCOPUS:84952039692

SN - 0143-5221

VL - 129

SP - 1225

EP - 1236

JO - Clinical Science

JF - Clinical Science

IS - 12

ER -

Vascular growth factors play critical roles in kidney glomeruli

Abstract

Keywords

UN SDGs

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