Vasopressin and oxytocin secretion in response to the consumption of ecstasy in a clubbing population

TY - JOUR

T1 - Vasopressin and oxytocin secretion in response to the consumption of ecstasy in a clubbing population

AU - Wolff, K

AU - Tsapakis, E M

AU - Winstock, A R

AU - Hartley, D

AU - Holt, D

AU - Forsling, M L

AU - Aitchison, K J

PY - 2006/5

Y1 - 2006/5

N2 - Despite the common use of MDMA (ecstasy) in the UK, the mechanism underlying associated potentially fatal cerebral oedema is unclear. We used a new experimental approach working directly with clubbers to perform a study on 30 (17 male) experienced clubbers (mean 6.6 years of clubbing). Pre- and post-ctubbing measurements were performed to compare plasma levels of pituitary hormones (vasopressin, oxytocin), plasma and urine osmolatity, urinary pH, and plasma sodium and urea. Ecstasy consumption was confirmed by using urinary drug screening pre and post-clubbing. MDMA was detected in the urine samples of 17 subjects, three of which tested positive during pre-clubbing tests. Mean plasma vasopressin concentration increased in the MDMA group (1.28 +/- 0.29 to 1.43 +/- 0.41 pmol/l), but fell in other participants (1.23 +/- 0.42 to 1.16 +/- 0.0.34pmol/l). Similarly, mean plasma oxytocin concentrations increased after ingestion of MDMA (2.02 +/- 0.29 to 2.43 +/- 0.24pmol/l), but fell in the group that did not use MDMA (2.17 +/- 0.36pmol/l to 1.89 +/- 0.37pmol/l). There was a significant group by time interaction for plasma osmolality and plasma sodium (p = 0.001 and p = 0.003, respectively) and between change in urinary osmolality (p <0.001) and MDMA use, with the pattern of change being consistent with the induction of inappropriate vasopressin secretion (also known as SIADH) by MDMA. This report demonstrates SIADH in ecstasy-using 'clubbers', which has important clinical implications

AB - Despite the common use of MDMA (ecstasy) in the UK, the mechanism underlying associated potentially fatal cerebral oedema is unclear. We used a new experimental approach working directly with clubbers to perform a study on 30 (17 male) experienced clubbers (mean 6.6 years of clubbing). Pre- and post-ctubbing measurements were performed to compare plasma levels of pituitary hormones (vasopressin, oxytocin), plasma and urine osmolatity, urinary pH, and plasma sodium and urea. Ecstasy consumption was confirmed by using urinary drug screening pre and post-clubbing. MDMA was detected in the urine samples of 17 subjects, three of which tested positive during pre-clubbing tests. Mean plasma vasopressin concentration increased in the MDMA group (1.28 +/- 0.29 to 1.43 +/- 0.41 pmol/l), but fell in other participants (1.23 +/- 0.42 to 1.16 +/- 0.0.34pmol/l). Similarly, mean plasma oxytocin concentrations increased after ingestion of MDMA (2.02 +/- 0.29 to 2.43 +/- 0.24pmol/l), but fell in the group that did not use MDMA (2.17 +/- 0.36pmol/l to 1.89 +/- 0.37pmol/l). There was a significant group by time interaction for plasma osmolality and plasma sodium (p = 0.001 and p = 0.003, respectively) and between change in urinary osmolality (p <0.001) and MDMA use, with the pattern of change being consistent with the induction of inappropriate vasopressin secretion (also known as SIADH) by MDMA. This report demonstrates SIADH in ecstasy-using 'clubbers', which has important clinical implications

U2 - 10.1177/0269881106061514

DO - 10.1177/0269881106061514

M3 - Article

SN - 1461-7285

VL - 20

SP - 400

EP - 410

JO - Journal of Psychopharmacology

JF - Journal of Psychopharmacology

IS - 3

ER -