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Ventral Striatum Connectivity During Reward Anticipation in Adolescent Smokers

Research output: Contribution to journalArticle

Lee Jollans, Cao Zhipeng, Ilknur Icke, Ciara Greene, Clare Kelly, Tobias Banaschewski, Arun L W Bokde, Uli Bromberg, Christian Büchel, Anna Cattrell, Patricia J Conrod, Sylvane Desrivières, Herta Flor, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot & 8 more Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Michael N Smolka, Henrik Walter, Gunter Schumann, Robert Whelan

Original languageEnglish
Pages (from-to)1-16
Number of pages16
JournalDevelopmental Neuropsychology
Early online date13 Apr 2016
DOIs
Publication statusE-pub ahead of print - 13 Apr 2016

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Abstract

Substance misusers, including adolescent smokers, often have reduced reward system activity during processing of non-drug rewards. Using a psychophysiological interaction approach, we examined functional connectivity with the ventral striatum during reward anticipation in a large (N = 206) sample of adolescent smokers. Increased smoking frequency was associated with (1) increased connectivity with regions involved in saliency and valuation, including the orbitofrontal cortex and (2) reduced connectivity between the ventral striatum and regions associated with inhibition and risk aversion, including the right inferior frontal gyrus. These results demonstrate that functional connectivity during reward processing is relevant to adolescent addiction.

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