Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood

Matthew D. Albaugh; Masha Ivanova; Bader Chaarani; Catherine Orr; Nicholas Allgaier; Robert R. Althoff; Nicholas D' Alberto; Kelsey Hudson; Scott Mackey; Philip A. Spechler; Tobias Banaschewski; Rüdiger Brühl; Arun L.W. Bokde; Uli Bromberg; Christian Büchel; Anna Cattrell; Patricia J. Conrod; Sylvane Desrivières; Herta Flor; Vincent Frouin; Jürgen Gallinat; Robert Goodman; Penny Gowland; Yvonne Grimmer; Andreas Heinz; Viola Kappel; Jean Luc Martinot; Marie Laure Paillère Martinot; Frauke Nees; Dimitri Papadopoulos Orfanos; Jani Penttilä; Luise Poustka; Tomáš Paus; Michael N. Smolka; Maren Struve; Henrik Walter; Robert Whelan; Gunter Schumann; Hugh Garavan; Alexandra S. Potter

doi:10.1093/cercor/bhy066

Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood

Matthew D. Albaugh, Masha Ivanova, Bader Chaarani, Catherine Orr, Nicholas Allgaier, Robert R. Althoff, Nicholas D' Alberto, Kelsey Hudson, Scott Mackey, Philip A. Spechler, Tobias Banaschewski, Rüdiger Brühl, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Anna Cattrell, Patricia J. Conrod, Sylvane Desrivières, Herta Flor, Vincent FrouinJürgen Gallinat, Robert Goodman, Penny Gowland, Yvonne Grimmer, Andreas Heinz, Viola Kappel, Jean Luc Martinot, Marie Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Jani Penttilä, Luise Poustka, Tomáš Paus, Michael N. Smolka, Maren Struve, Henrik Walter, Robert Whelan, Gunter Schumann, Hugh Garavan, Alexandra S. Potter

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1104 participants (M = 14.52 years, standard deviation = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = -0.274, P < 0.001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms.

Original language	English
Article number	bhy066
Pages (from-to)	1866-1874
Number of pages	9
Journal	Cerebral cortex (New York, N.Y. : 1991)
Volume	29
Issue number	5
DOIs	https://doi.org/10.1093/cercor/bhy066
Publication status	Published - 1 May 2019

Keywords

attention-deficit/hyperactivity disorder
neuroimaging
ventromedial prefrontal cortex

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10.1093/cercor/bhy066

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Albaugh, M. D., Ivanova, M., Chaarani, B., Orr, C., Allgaier, N., Althoff, R. R., D' Alberto, N., Hudson, K., Mackey, S., Spechler, P. A., Banaschewski, T., Brühl, R., Bokde, A. L. W., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P. J., Desrivières, S., Flor, H., ... Potter, A. S. (2019). Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood. Cerebral cortex (New York, N.Y. : 1991), 29(5), 1866-1874. Article bhy066. https://doi.org/10.1093/cercor/bhy066

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title = "Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood",

abstract = "Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1104 participants (M = 14.52 years, standard deviation = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = -0.274, P < 0.001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms.",

keywords = "attention-deficit/hyperactivity disorder, neuroimaging, ventromedial prefrontal cortex",

author = "Albaugh, {Matthew D.} and Masha Ivanova and Bader Chaarani and Catherine Orr and Nicholas Allgaier and Althoff, {Robert R.} and {D' Alberto}, Nicholas and Kelsey Hudson and Scott Mackey and Spechler, {Philip A.} and Tobias Banaschewski and R{\"u}diger Br{\"u}hl and Bokde, {Arun L.W.} and Uli Bromberg and Christian B{\"u}chel and Anna Cattrell and Conrod, {Patricia J.} and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and J{\"u}rgen Gallinat and Robert Goodman and Penny Gowland and Yvonne Grimmer and Andreas Heinz and Viola Kappel and Martinot, {Jean Luc} and Martinot, {Marie Laure Paill{\`e}re} and Frauke Nees and {Papadopoulos Orfanos}, Dimitri and Jani Penttil{\"a} and Luise Poustka and Tom{\'a}{\v s} Paus and Smolka, {Michael N.} and Maren Struve and Henrik Walter and Robert Whelan and Gunter Schumann and Hugh Garavan and Potter, {Alexandra S.}",

year = "2019",

month = may,

day = "1",

doi = "10.1093/cercor/bhy066",

language = "English",

volume = "29",

pages = "1866--1874",

journal = "Cerebral cortex (New York, N.Y. : 1991)",

issn = "1047-3211",

publisher = "Oxford University Press",

number = "5",

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Albaugh, MD, Ivanova, M, Chaarani, B, Orr, C, Allgaier, N, Althoff, RR, D' Alberto, N, Hudson, K, Mackey, S, Spechler, PA, Banaschewski, T, Brühl, R, Bokde, ALW, Bromberg, U, Büchel, C, Cattrell, A , Conrod, PJ , Desrivières, S, Flor, H, Frouin, V, Gallinat, J, Goodman, R, Gowland, P, Grimmer, Y, Heinz, A, Kappel, V, Martinot, JL, Martinot, MLP, Nees, F, Papadopoulos Orfanos, D, Penttilä, J, Poustka, L, Paus, T, Smolka, MN, Struve, M, Walter, H, Whelan, R, Schumann, G, Garavan, H & Potter, AS 2019, 'Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood', Cerebral cortex (New York, N.Y. : 1991), vol. 29, no. 5, bhy066, pp. 1866-1874. https://doi.org/10.1093/cercor/bhy066

TY - JOUR

T1 - Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood

AU - Albaugh, Matthew D.

AU - Ivanova, Masha

AU - Chaarani, Bader

AU - Orr, Catherine

AU - Allgaier, Nicholas

AU - Althoff, Robert R.

AU - D' Alberto, Nicholas

AU - Hudson, Kelsey

AU - Mackey, Scott

AU - Spechler, Philip A.

AU - Banaschewski, Tobias

AU - Brühl, Rüdiger

AU - Bokde, Arun L.W.

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Cattrell, Anna

AU - Conrod, Patricia J.

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Gallinat, Jürgen

AU - Goodman, Robert

AU - Gowland, Penny

AU - Grimmer, Yvonne

AU - Heinz, Andreas

AU - Kappel, Viola

AU - Martinot, Jean Luc

AU - Martinot, Marie Laure Paillère

AU - Nees, Frauke

AU - Papadopoulos Orfanos, Dimitri

AU - Penttilä, Jani

AU - Poustka, Luise

AU - Paus, Tomáš

AU - Smolka, Michael N.

AU - Struve, Maren

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Garavan, Hugh

AU - Potter, Alexandra S.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1104 participants (M = 14.52 years, standard deviation = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = -0.274, P < 0.001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms.

AB - Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1104 participants (M = 14.52 years, standard deviation = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = -0.274, P < 0.001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms.

KW - attention-deficit/hyperactivity disorder

KW - neuroimaging

KW - ventromedial prefrontal cortex

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U2 - 10.1093/cercor/bhy066

DO - 10.1093/cercor/bhy066

M3 - Article

C2 - 29912404

AN - SCOPUS:85064685720

SN - 1047-3211

VL - 29

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EP - 1874

JO - Cerebral cortex (New York, N.Y. : 1991)

JF - Cerebral cortex (New York, N.Y. : 1991)

IS - 5

M1 - bhy066

ER -

Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood

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