Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood

Matthew D. Albaugh, Masha Ivanova, Bader Chaarani, Catherine Orr, Nicholas Allgaier, Robert R. Althoff, Nicholas D' Alberto, Kelsey Hudson, Scott Mackey, Philip A. Spechler, Tobias Banaschewski, Rüdiger Brühl, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Anna Cattrell, Patricia J. Conrod, Sylvane Desrivières, Herta Flor, Vincent FrouinJürgen Gallinat, Robert Goodman, Penny Gowland, Yvonne Grimmer, Andreas Heinz, Viola Kappel, Jean Luc Martinot, Marie Laure Paillère Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Jani Penttilä, Luise Poustka, Tomáš Paus, Michael N. Smolka, Maren Struve, Henrik Walter, Robert Whelan, Gunter Schumann, Hugh Garavan, Alexandra S. Potter

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1104 participants (M = 14.52 years, standard deviation = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = -0.274, P < 0.001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms.

Original languageEnglish
Article numberbhy066
Pages (from-to)1866-1874
Number of pages9
JournalCerebral cortex (New York, N.Y. : 1991)
Issue number5
Publication statusPublished - 1 May 2019


  • attention-deficit/hyperactivity disorder
  • neuroimaging
  • ventromedial prefrontal cortex


Dive into the research topics of 'Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood'. Together they form a unique fingerprint.

Cite this