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Verbal fluency in cerebral small vessel disease and Alzheimer's disease

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Verbal fluency in cerebral small vessel disease and Alzheimer's disease. / Herbert, Vanessa; Brooks, Rebecca; Markus, Hugh S.; Morris, Robin.

In: Journal of the International Neuropsychological Society, Vol. 20, No. 4, 04.2014, p. 413-421.

Research output: Contribution to journalArticlepeer-review

Harvard

Herbert, V, Brooks, R, Markus, HS & Morris, R 2014, 'Verbal fluency in cerebral small vessel disease and Alzheimer's disease', Journal of the International Neuropsychological Society, vol. 20, no. 4, pp. 413-421. https://doi.org/10.1017/S1355617714000101

APA

Herbert, V., Brooks, R., Markus, H. S., & Morris, R. (2014). Verbal fluency in cerebral small vessel disease and Alzheimer's disease. Journal of the International Neuropsychological Society, 20(4), 413-421. https://doi.org/10.1017/S1355617714000101

Vancouver

Herbert V, Brooks R, Markus HS, Morris R. Verbal fluency in cerebral small vessel disease and Alzheimer's disease. Journal of the International Neuropsychological Society. 2014 Apr;20(4):413-421. https://doi.org/10.1017/S1355617714000101

Author

Herbert, Vanessa ; Brooks, Rebecca ; Markus, Hugh S. ; Morris, Robin. / Verbal fluency in cerebral small vessel disease and Alzheimer's disease. In: Journal of the International Neuropsychological Society. 2014 ; Vol. 20, No. 4. pp. 413-421.

Bibtex Download

@article{b2b410b698274d0cbd2f519cf27433e4,
title = "Verbal fluency in cerebral small vessel disease and Alzheimer's disease",
abstract = "Patterns of verbal fluency deficits have been explored across different neurodegenerative disorders. This study sought to investigate the specific pattern of verbal fluency performance in cerebral small vessel disease (SVD), which is the most common cause of vascular cognitive impairment, and compare this with Alzheimer's disease (AD). Participants with SVD (n = 45), AD (n = 24) and healthy controls (n = 80) completed assessments of semantic and phonemic fluency. Mixed-model analyses of covariance were used to compare performance on the different fluency tasks between the groups, and a discriminant function analysis was conducted to examine group differentiation. The SVD group was impaired in both fluency tasks when compared to the controls. In contrast, the AD group displayed impairment in semantic fluency only. Discriminant function analysis revealed that fluency scores correctly classified 80% of SVD patients and 92% of AD patients. The pattern of performance observed in the SVD group may reflect deficits in executive function and processing speed impacting equivalently on semantic and phonemic fluency. The differences between the SVD and AD groups highlighted in this study may be useful for distinguishing between these conditions.",
keywords = "small vessel disease, diagnosis, neuropsychology",
author = "Vanessa Herbert and Rebecca Brooks and Markus, {Hugh S.} and Robin Morris",
year = "2014",
month = apr,
doi = "10.1017/S1355617714000101",
language = "English",
volume = "20",
pages = "413--421",
journal = "Journal of the International Neuropsychological Society",
issn = "1355-6177",
publisher = "Cambridge University Press",
number = "4",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Verbal fluency in cerebral small vessel disease and Alzheimer's disease

AU - Herbert, Vanessa

AU - Brooks, Rebecca

AU - Markus, Hugh S.

AU - Morris, Robin

PY - 2014/4

Y1 - 2014/4

N2 - Patterns of verbal fluency deficits have been explored across different neurodegenerative disorders. This study sought to investigate the specific pattern of verbal fluency performance in cerebral small vessel disease (SVD), which is the most common cause of vascular cognitive impairment, and compare this with Alzheimer's disease (AD). Participants with SVD (n = 45), AD (n = 24) and healthy controls (n = 80) completed assessments of semantic and phonemic fluency. Mixed-model analyses of covariance were used to compare performance on the different fluency tasks between the groups, and a discriminant function analysis was conducted to examine group differentiation. The SVD group was impaired in both fluency tasks when compared to the controls. In contrast, the AD group displayed impairment in semantic fluency only. Discriminant function analysis revealed that fluency scores correctly classified 80% of SVD patients and 92% of AD patients. The pattern of performance observed in the SVD group may reflect deficits in executive function and processing speed impacting equivalently on semantic and phonemic fluency. The differences between the SVD and AD groups highlighted in this study may be useful for distinguishing between these conditions.

AB - Patterns of verbal fluency deficits have been explored across different neurodegenerative disorders. This study sought to investigate the specific pattern of verbal fluency performance in cerebral small vessel disease (SVD), which is the most common cause of vascular cognitive impairment, and compare this with Alzheimer's disease (AD). Participants with SVD (n = 45), AD (n = 24) and healthy controls (n = 80) completed assessments of semantic and phonemic fluency. Mixed-model analyses of covariance were used to compare performance on the different fluency tasks between the groups, and a discriminant function analysis was conducted to examine group differentiation. The SVD group was impaired in both fluency tasks when compared to the controls. In contrast, the AD group displayed impairment in semantic fluency only. Discriminant function analysis revealed that fluency scores correctly classified 80% of SVD patients and 92% of AD patients. The pattern of performance observed in the SVD group may reflect deficits in executive function and processing speed impacting equivalently on semantic and phonemic fluency. The differences between the SVD and AD groups highlighted in this study may be useful for distinguishing between these conditions.

KW - small vessel disease

KW - diagnosis

KW - neuropsychology

U2 - 10.1017/S1355617714000101

DO - 10.1017/S1355617714000101

M3 - Article

VL - 20

SP - 413

EP - 421

JO - Journal of the International Neuropsychological Society

JF - Journal of the International Neuropsychological Society

SN - 1355-6177

IS - 4

ER -

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