Very prematurely born infants wheezing at follow-up: lung function and risk factors

Simon Broughton; Mark R Thomas; Louise Marston; Sandra A Calvert; Neil Marlow; Janet L Peacock; Gerrard F Rafferty; Anne Greenough

doi:10.1136/adc.2006.112623

Very prematurely born infants wheezing at follow-up: lung function and risk factors

Simon Broughton, Mark R Thomas, Louise Marston, Sandra A Calvert, Neil Marlow, Janet L Peacock, Gerrard F Rafferty, Anne Greenough

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Objectives: To determine whether abnormalities of lung volume and/or airway function were associated with wheeze at follow-up in infants born very prematurely and to identify risk factors for wheeze.

Design: Lung function data obtained at 1 year of age were collated from two cohorts of infants recruited into the UKOS and an RSV study, respectively.

Setting: Infant pulmonary function laboratory.

Patients: 111 infants (mean gestational age 26.3 (SD 1.6) weeks).

Interventions: Lung function measurements at 1 year of age corrected for gestational age at birth. Diary cards and respiratory questionnaires were completed to document wheeze.

Main outcome measures: Functional residual capacity (FRCpleth and FRCHe), airways resistance (Raw), FRCHe:FRCpleth and tidal breathing parameters (TPTEF:TE).

Results: The 60 infants who wheezed at follow-up had significantly lower mean FRCHe, FRCHe:FRCpleth and TPTEF:TE, but higher mean Raw than the 51 without wheeze. Regression analysis demonstrated that gestational age, length at assessment, family history of atopy and a low FRCHe:FRCpleth were significantly associated with wheeze.

Conclusions: Wheeze at follow-up in very prematurely born infants is associated with gas trapping, suggesting abnormalities of the small airways.

Original language	English
Pages (from-to)	776 - 780
Number of pages	5
Journal	Archives of Disease in Childhood
Volume	92
Issue number	9
DOIs	https://doi.org/10.1136/adc.2006.112623
Publication status	Published - Sept 2007

Keywords

Infant
Respiratory Sounds
Functional Residual Capacity
Risk Factors
Humans
Respiration Disorders
Infant, Newborn
Infant, Premature, Diseases
Follow-Up Studies
Infant, Premature
Male
Female

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10.1136/adc.2006.112623

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title = "Very prematurely born infants wheezing at follow-up: lung function and risk factors",

abstract = "Objectives: To determine whether abnormalities of lung volume and/or airway function were associated with wheeze at follow-up in infants born very prematurely and to identify risk factors for wheeze.Design: Lung function data obtained at 1 year of age were collated from two cohorts of infants recruited into the UKOS and an RSV study, respectively.Setting: Infant pulmonary function laboratory.Patients: 111 infants (mean gestational age 26.3 (SD 1.6) weeks).Interventions: Lung function measurements at 1 year of age corrected for gestational age at birth. Diary cards and respiratory questionnaires were completed to document wheeze.Main outcome measures: Functional residual capacity (FRCpleth and FRCHe), airways resistance (Raw), FRCHe:FRCpleth and tidal breathing parameters (TPTEF:TE).Results: The 60 infants who wheezed at follow-up had significantly lower mean FRCHe, FRCHe:FRCpleth and TPTEF:TE, but higher mean Raw than the 51 without wheeze. Regression analysis demonstrated that gestational age, length at assessment, family history of atopy and a low FRCHe:FRCpleth were significantly associated with wheeze.Conclusions: Wheeze at follow-up in very prematurely born infants is associated with gas trapping, suggesting abnormalities of the small airways.",

keywords = "Infant, Respiratory Sounds, Functional Residual Capacity, Risk Factors, Humans, Respiration Disorders, Infant, Newborn, Infant, Premature, Diseases, Follow-Up Studies, Infant, Premature, Male, Female",

author = "Simon Broughton and Thomas, {Mark R} and Louise Marston and Calvert, {Sandra A} and Neil Marlow and Peacock, {Janet L} and Rafferty, {Gerrard F} and Anne Greenough",

year = "2007",

month = sep,

doi = "10.1136/adc.2006.112623",

language = "English",

volume = "92",

pages = "776 -- 780",

journal = "Archives of Disease in Childhood",

issn = "1468-2044",

publisher = "BMJ Publishing Group Ltd",

number = "9",

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T1 - Very prematurely born infants wheezing at follow-up

T2 - lung function and risk factors

AU - Broughton, Simon

AU - Thomas, Mark R

AU - Marston, Louise

AU - Calvert, Sandra A

AU - Marlow, Neil

AU - Peacock, Janet L

AU - Rafferty, Gerrard F

AU - Greenough, Anne

PY - 2007/9

Y1 - 2007/9

N2 - Objectives: To determine whether abnormalities of lung volume and/or airway function were associated with wheeze at follow-up in infants born very prematurely and to identify risk factors for wheeze.Design: Lung function data obtained at 1 year of age were collated from two cohorts of infants recruited into the UKOS and an RSV study, respectively.Setting: Infant pulmonary function laboratory.Patients: 111 infants (mean gestational age 26.3 (SD 1.6) weeks).Interventions: Lung function measurements at 1 year of age corrected for gestational age at birth. Diary cards and respiratory questionnaires were completed to document wheeze.Main outcome measures: Functional residual capacity (FRCpleth and FRCHe), airways resistance (Raw), FRCHe:FRCpleth and tidal breathing parameters (TPTEF:TE).Results: The 60 infants who wheezed at follow-up had significantly lower mean FRCHe, FRCHe:FRCpleth and TPTEF:TE, but higher mean Raw than the 51 without wheeze. Regression analysis demonstrated that gestational age, length at assessment, family history of atopy and a low FRCHe:FRCpleth were significantly associated with wheeze.Conclusions: Wheeze at follow-up in very prematurely born infants is associated with gas trapping, suggesting abnormalities of the small airways.

AB - Objectives: To determine whether abnormalities of lung volume and/or airway function were associated with wheeze at follow-up in infants born very prematurely and to identify risk factors for wheeze.Design: Lung function data obtained at 1 year of age were collated from two cohorts of infants recruited into the UKOS and an RSV study, respectively.Setting: Infant pulmonary function laboratory.Patients: 111 infants (mean gestational age 26.3 (SD 1.6) weeks).Interventions: Lung function measurements at 1 year of age corrected for gestational age at birth. Diary cards and respiratory questionnaires were completed to document wheeze.Main outcome measures: Functional residual capacity (FRCpleth and FRCHe), airways resistance (Raw), FRCHe:FRCpleth and tidal breathing parameters (TPTEF:TE).Results: The 60 infants who wheezed at follow-up had significantly lower mean FRCHe, FRCHe:FRCpleth and TPTEF:TE, but higher mean Raw than the 51 without wheeze. Regression analysis demonstrated that gestational age, length at assessment, family history of atopy and a low FRCHe:FRCpleth were significantly associated with wheeze.Conclusions: Wheeze at follow-up in very prematurely born infants is associated with gas trapping, suggesting abnormalities of the small airways.

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KW - Respiratory Sounds

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KW - Risk Factors

KW - Humans

KW - Respiration Disorders

KW - Infant, Newborn

KW - Infant, Premature, Diseases

KW - Follow-Up Studies

KW - Infant, Premature

KW - Male

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U2 - 10.1136/adc.2006.112623

DO - 10.1136/adc.2006.112623

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SN - 1468-2044

VL - 92

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EP - 780

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

IS - 9

ER -

Very prematurely born infants wheezing at follow-up: lung function and risk factors

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Keywords

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