Very prematurely born infants wheezing at follow-up: lung function and risk factors

Simon Broughton, Mark R Thomas, Louise Marston, Sandra A Calvert, Neil Marlow, Janet L Peacock, Gerrard F Rafferty, Anne Greenough

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


Objectives: To determine whether abnormalities of lung volume and/or airway function were associated with wheeze at follow-up in infants born very prematurely and to identify risk factors for wheeze.

Design: Lung function data obtained at 1 year of age were collated from two cohorts of infants recruited into the UKOS and an RSV study, respectively.

Setting: Infant pulmonary function laboratory.

Patients: 111 infants (mean gestational age 26.3 (SD 1.6) weeks).

Interventions: Lung function measurements at 1 year of age corrected for gestational age at birth. Diary cards and respiratory questionnaires were completed to document wheeze.

Main outcome measures: Functional residual capacity (FRCpleth and FRCHe), airways resistance (Raw), FRCHe:FRCpleth and tidal breathing parameters (TPTEF:TE).

Results: The 60 infants who wheezed at follow-up had significantly lower mean FRCHe, FRCHe:FRCpleth and TPTEF:TE, but higher mean Raw than the 51 without wheeze. Regression analysis demonstrated that gestational age, length at assessment, family history of atopy and a low FRCHe:FRCpleth were significantly associated with wheeze.

Conclusions: Wheeze at follow-up in very prematurely born infants is associated with gas trapping, suggesting abnormalities of the small airways.
Original languageEnglish
Pages (from-to)776 - 780
Number of pages5
JournalArchives of Disease in Childhood
Issue number9
Publication statusPublished - Sept 2007


  • Infant
  • Respiratory Sounds
  • Functional Residual Capacity
  • Risk Factors
  • Humans
  • Respiration Disorders
  • Infant, Newborn
  • Infant, Premature, Diseases
  • Follow-Up Studies
  • Infant, Premature
  • Male
  • Female


Dive into the research topics of 'Very prematurely born infants wheezing at follow-up: lung function and risk factors'. Together they form a unique fingerprint.

Cite this