Visualisation of the heterogeneous water sorption in a pharmaceutical formulation under controlled humidity via FT-IR imaging

TY - JOUR

T1 - Visualisation of the heterogeneous water sorption in a pharmaceutical formulation under controlled humidity via FT-IR imaging

AU - Chan, KLA

AU - Kazarian, SG

PY - 2004/6/17

Y1 - 2004/6/17

N2 - Opportunities exist to study sorption of water vapour into the domains of different components in heterogeneous polymeric materials via FT-IR spectroscopic imaging. This information is needed to understand the behaviour of pharmaceutical formulations under different humidity. Sorption of water in a polyethylene glycol (PEG) - griseofulvin mixture subjected to a range of relative humidity (RH) from 0.5 to 90% at a temperature of 25 degreesC has been studied via FT-IR imaging in situ using a controlled humidity transmission cell. This approach offers visualisation of the water sorption in different domains of the sample (polymer and drug). The FT-IR imaging data have shown that water sorption occurs preferentially in the domains of PEG rather than in the domains of griseofulvin. Significant increase of water sorption has been observed at a RH above 70%. The spatial distribution of the drug in the polymer did not change in the studied sample in the range of RH from 0.5 to 90%.

AB - Opportunities exist to study sorption of water vapour into the domains of different components in heterogeneous polymeric materials via FT-IR spectroscopic imaging. This information is needed to understand the behaviour of pharmaceutical formulations under different humidity. Sorption of water in a polyethylene glycol (PEG) - griseofulvin mixture subjected to a range of relative humidity (RH) from 0.5 to 90% at a temperature of 25 degreesC has been studied via FT-IR imaging in situ using a controlled humidity transmission cell. This approach offers visualisation of the water sorption in different domains of the sample (polymer and drug). The FT-IR imaging data have shown that water sorption occurs preferentially in the domains of PEG rather than in the domains of griseofulvin. Significant increase of water sorption has been observed at a RH above 70%. The spatial distribution of the drug in the polymer did not change in the studied sample in the range of RH from 0.5 to 90%.

KW - polymers

KW - drugs

KW - FTIR spectroscopy

KW - transmission

KW - relative humidity

KW - moisture

KW - POLY(ETHYLENE GLYCOL) FILMS

KW - POLYMER DISSOLUTION

KW - VAPOR

KW - RELEASE

KW - STATE

U2 - 10.1016/j.vibspec.2003.11.005

DO - 10.1016/j.vibspec.2003.11.005

M3 - Article

SN - 0924-2031

VL - 35

SP - 45

EP - 49

JO - VIBRATIONAL SPECTROSCOPY

JF - VIBRATIONAL SPECTROSCOPY

IS - 1-2

T2 - 2nd International Conference on Advanced Vibrational Spectroscopy

Y2 - 24 August 2003 through 29 August 2003

ER -