Vitamin D and risk of CVD: A review of the evidence

Catherine M. Fry*, Thomas A B Sanders

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    25 Citations (Scopus)


    This review summarises evidence for an association between vitamin D status and CVD and the mechanisms involved. Vitamin D3 is predominantly provided by the action of UVB from sunlight on skin. Average UK diets supply 2-3 μg/d vitamin D but diets containing at least one portion of oily fish per week supply about 7 μg/d. Pharmacological doses of vitamin D2 (bolus injection of 7500 μg or intakes >50 μg/d) result in a smaller increase in plasma 25(OH)D than those of D3 but physiological doses 5-25 μg/d seem equivalent. Plasma 25(OH)D concentrations are also influenced by clothing, obesity and skin pigmentation. Up to 40% of the population have plasma 25(OH)D concentrations 2 and D3 with CVD incidence as the primary outcome.

    Original languageEnglish
    Pages (from-to)245-257
    Number of pages13
    JournalProceedings of the Nutrition Society
    Issue number3
    Publication statusPublished - 21 Aug 2015


    • Cardiovascular risk
    • Cholecalciferol
    • Ergocalciferol


    Dive into the research topics of 'Vitamin D and risk of CVD: A review of the evidence'. Together they form a unique fingerprint.

    Cite this