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Vitamin D and skeletal muscle strength and endurance in COPD

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Vitamin D and skeletal muscle strength and endurance in COPD. / Jackson, Abigail S.; Shrikrishna, Dinesh; Kelly, Julia L.; Hart, Nicholas; Moxham, John; Polkey, Michael I.; Kemp, Paul; Hopkinson, Nicholas S.

In: European Respiratory Journal, Vol. 41, No. 2, 01.02.2013, p. 309-316.

Research output: Contribution to journalArticle

Harvard

Jackson, AS, Shrikrishna, D, Kelly, JL, Hart, N, Moxham, J, Polkey, MI, Kemp, P & Hopkinson, NS 2013, 'Vitamin D and skeletal muscle strength and endurance in COPD' European Respiratory Journal, vol 41, no. 2, pp. 309-316. DOI: 10.1183/09031936.00043112

APA

Jackson, A. S., Shrikrishna, D., Kelly, J. L., Hart, N., Moxham, J., Polkey, M. I., ... Hopkinson, N. S. (2013). Vitamin D and skeletal muscle strength and endurance in COPD. European Respiratory Journal, 41(2), 309-316. DOI: 10.1183/09031936.00043112

Vancouver

Jackson AS, Shrikrishna D, Kelly JL, Hart N, Moxham J, Polkey MI et al. Vitamin D and skeletal muscle strength and endurance in COPD. European Respiratory Journal. 2013 Feb 1;41(2):309-316. Available from, DOI: 10.1183/09031936.00043112

Author

Jackson, Abigail S.; Shrikrishna, Dinesh; Kelly, Julia L.; Hart, Nicholas; Moxham, John; Polkey, Michael I.; Kemp, Paul; Hopkinson, Nicholas S. / Vitamin D and skeletal muscle strength and endurance in COPD.

In: European Respiratory Journal, Vol. 41, No. 2, 01.02.2013, p. 309-316.

Research output: Contribution to journalArticle

Bibtex Download

@article{3c175e4096e04ba4bd1c460f5126932b,
title = "Vitamin D and skeletal muscle strength and endurance in COPD",
keywords = "Chronic obstructive pulmonary disease, fibre type, magnetic stimulation, muscle, quadriceps, vitamin D, OBSTRUCTIVE PULMONARY-DISEASE, D-RECEPTOR GENOTYPE, TRANSCRIPTION FACTORS, QUADRICEPS STRENGTH, TELOMERE LENGTH, OLDER-ADULTS, NORMAL WOMEN, D DEFICIENCY, CELLS, FALLS",
author = "Jackson, {Abigail S.} and Dinesh Shrikrishna and Kelly, {Julia L.} and Nicholas Hart and John Moxham and Polkey, {Michael I.} and Paul Kemp and Hopkinson, {Nicholas S.}",
note = "Open Access",
year = "2013",
month = "2",
doi = "10.1183/09031936.00043112",
volume = "41",
pages = "309--316",
journal = "European Respiratory Journal",
issn = "0903-1936",
number = "2",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Vitamin D and skeletal muscle strength and endurance in COPD

AU - Jackson,Abigail S.

AU - Shrikrishna,Dinesh

AU - Kelly,Julia L.

AU - Hart,Nicholas

AU - Moxham,John

AU - Polkey,Michael I.

AU - Kemp,Paul

AU - Hopkinson,Nicholas S.

N1 - Open Access

PY - 2013/2/1

Y1 - 2013/2/1

N2 - <p>It is not known whether vitamin D levels make a significant contribution to muscle dysfunction in chronic obstructive pulmonary disease (COPD).</p><p>In 104 COPD patients (mean +/- SD forced expiratory volume in 1 s 44 +/- 22 % predicted) and 100 age- and sex-matched controls, serum 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)(2)D) and parathyroid hormone (PTH) levels were measured and related to quadriceps strength and endurance. In a subset of 26 patients and 13 controls, quadriceps biopsy was performed and mRNA expression of myogenic regulatory factors (mrf) and fibre-specific myosin heavy chains (MHC) was determined.</p><p>COPD patients were weaker and less physically active than controls. 25(OH)D levels were similar in both groups (48.5 +/- 25.5 nmol.L-1 COPD versus 55.4 +/- 28.3 nmol.L-1 control, p=0.07) but PTH levels were significantly higher in patients (5.2 +/- 2.3 pmol.mL(-1) versus 4.4 +/- 2.0 pmol.L-1, p=0.01). 1,25(OH)D was significantly correlated with strength in controls, but not in COPD patients and not with quadriceps endurance assessed using repetitive magnetic stimulation in COPD (n=35) or control (n=35) subjects. In controls, but not COPD patients, muscle biopsy analysis showed a negative relationship between 25(OH)D and MHCIla expression (r(2)=0.5, p=0.01) and a positive relationship between mrf4 and MHCIla expression (r(2)=0.5, p=0.009), and myogenic regulatory factor myf5 and MHCl expression (r(2)=0.72, p=0.004).</p><p>In contrast with healthy controls, muscle strength is not associated with vitamin D levels in COPD, which may represent vitamin D resistance.</p>

AB - <p>It is not known whether vitamin D levels make a significant contribution to muscle dysfunction in chronic obstructive pulmonary disease (COPD).</p><p>In 104 COPD patients (mean +/- SD forced expiratory volume in 1 s 44 +/- 22 % predicted) and 100 age- and sex-matched controls, serum 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)(2)D) and parathyroid hormone (PTH) levels were measured and related to quadriceps strength and endurance. In a subset of 26 patients and 13 controls, quadriceps biopsy was performed and mRNA expression of myogenic regulatory factors (mrf) and fibre-specific myosin heavy chains (MHC) was determined.</p><p>COPD patients were weaker and less physically active than controls. 25(OH)D levels were similar in both groups (48.5 +/- 25.5 nmol.L-1 COPD versus 55.4 +/- 28.3 nmol.L-1 control, p=0.07) but PTH levels were significantly higher in patients (5.2 +/- 2.3 pmol.mL(-1) versus 4.4 +/- 2.0 pmol.L-1, p=0.01). 1,25(OH)D was significantly correlated with strength in controls, but not in COPD patients and not with quadriceps endurance assessed using repetitive magnetic stimulation in COPD (n=35) or control (n=35) subjects. In controls, but not COPD patients, muscle biopsy analysis showed a negative relationship between 25(OH)D and MHCIla expression (r(2)=0.5, p=0.01) and a positive relationship between mrf4 and MHCIla expression (r(2)=0.5, p=0.009), and myogenic regulatory factor myf5 and MHCl expression (r(2)=0.72, p=0.004).</p><p>In contrast with healthy controls, muscle strength is not associated with vitamin D levels in COPD, which may represent vitamin D resistance.</p>

KW - Chronic obstructive pulmonary disease

KW - fibre type

KW - magnetic stimulation

KW - muscle

KW - quadriceps

KW - vitamin D

KW - OBSTRUCTIVE PULMONARY-DISEASE

KW - D-RECEPTOR GENOTYPE

KW - TRANSCRIPTION FACTORS

KW - QUADRICEPS STRENGTH

KW - TELOMERE LENGTH

KW - OLDER-ADULTS

KW - NORMAL WOMEN

KW - D DEFICIENCY

KW - CELLS

KW - FALLS

U2 - 10.1183/09031936.00043112

DO - 10.1183/09031936.00043112

M3 - Article

VL - 41

SP - 309

EP - 316

JO - European Respiratory Journal

T2 - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 2

ER -

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