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Vitamin D deficiency and its role in muscle-bone interactions in the elderly

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Vitamin D deficiency and its role in muscle-bone interactions in the elderly. / Sanders, Kerrie M; Scott, David; Ebeling, Peter R.

In: Current osteoporosis reports, Vol. 12, No. 1, 03.2014, p. 74-81.

Research output: Contribution to journalArticle

Harvard

Sanders, KM, Scott, D & Ebeling, PR 2014, 'Vitamin D deficiency and its role in muscle-bone interactions in the elderly', Current osteoporosis reports, vol. 12, no. 1, pp. 74-81. https://doi.org/10.1007/s11914-014-0193-4

APA

Sanders, K. M., Scott, D., & Ebeling, P. R. (2014). Vitamin D deficiency and its role in muscle-bone interactions in the elderly. Current osteoporosis reports, 12(1), 74-81. https://doi.org/10.1007/s11914-014-0193-4

Vancouver

Sanders KM, Scott D, Ebeling PR. Vitamin D deficiency and its role in muscle-bone interactions in the elderly. Current osteoporosis reports. 2014 Mar;12(1):74-81. https://doi.org/10.1007/s11914-014-0193-4

Author

Sanders, Kerrie M ; Scott, David ; Ebeling, Peter R. / Vitamin D deficiency and its role in muscle-bone interactions in the elderly. In: Current osteoporosis reports. 2014 ; Vol. 12, No. 1. pp. 74-81.

Bibtex Download

@article{970f5c13ac2b40b88190b0bde872bca1,
title = "Vitamin D deficiency and its role in muscle-bone interactions in the elderly",
abstract = "In this commentary, we focus on common 'downstream' links of vitamin D between muscle and bone health. Both direct and indirect effects of 1,25 dihydroxyvitamin D (1,25(OH)D) link the mutual age-related decline in muscle function and bone density, independent of physical activity. Changes in calcium absorption associated with vitamin D deficiency affect both muscle and bone mass. The age-related decline in vitamin D receptor expression and 1,25(OH)D activity impact on proinflammatory cytokines such as tumor necrosis factor -α and interleukin-6 in skeletal muscle and vitamin D deficiency appears to enhance both bone marrow adipogenesis and intramuscular adipose tissue impacting as reduced functionality in both skeletal tissues. Controversial findings on the role of 1,25(OH)D on skeletal muscle may relate to differences in vitamin D receptor expression throughout different stages of muscle cell differentiation. Prolonged vitamin D insufficiency in the elderly is associated with reductions in both bone mineral density and type 2 muscle fibers with the outcomes of skeletal fragility in combination with reduced muscle power, leading to increased risk of falls and fracture.",
keywords = "Accidental Falls, Aged, Bone Density, Bone Diseases, Metabolic, Calcitriol, Fractures, Bone, Humans, Muscle Fibers, Fast-Twitch, Muscle Strength, Muscle, Skeletal, Sarcopenia, Vitamin D Deficiency",
author = "Sanders, {Kerrie M} and David Scott and Ebeling, {Peter R}",
year = "2014",
month = mar,
doi = "10.1007/s11914-014-0193-4",
language = "English",
volume = "12",
pages = "74--81",
journal = "Current osteoporosis reports",
issn = "1544-2241",
publisher = "Current Science, Inc.",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Vitamin D deficiency and its role in muscle-bone interactions in the elderly

AU - Sanders, Kerrie M

AU - Scott, David

AU - Ebeling, Peter R

PY - 2014/3

Y1 - 2014/3

N2 - In this commentary, we focus on common 'downstream' links of vitamin D between muscle and bone health. Both direct and indirect effects of 1,25 dihydroxyvitamin D (1,25(OH)D) link the mutual age-related decline in muscle function and bone density, independent of physical activity. Changes in calcium absorption associated with vitamin D deficiency affect both muscle and bone mass. The age-related decline in vitamin D receptor expression and 1,25(OH)D activity impact on proinflammatory cytokines such as tumor necrosis factor -α and interleukin-6 in skeletal muscle and vitamin D deficiency appears to enhance both bone marrow adipogenesis and intramuscular adipose tissue impacting as reduced functionality in both skeletal tissues. Controversial findings on the role of 1,25(OH)D on skeletal muscle may relate to differences in vitamin D receptor expression throughout different stages of muscle cell differentiation. Prolonged vitamin D insufficiency in the elderly is associated with reductions in both bone mineral density and type 2 muscle fibers with the outcomes of skeletal fragility in combination with reduced muscle power, leading to increased risk of falls and fracture.

AB - In this commentary, we focus on common 'downstream' links of vitamin D between muscle and bone health. Both direct and indirect effects of 1,25 dihydroxyvitamin D (1,25(OH)D) link the mutual age-related decline in muscle function and bone density, independent of physical activity. Changes in calcium absorption associated with vitamin D deficiency affect both muscle and bone mass. The age-related decline in vitamin D receptor expression and 1,25(OH)D activity impact on proinflammatory cytokines such as tumor necrosis factor -α and interleukin-6 in skeletal muscle and vitamin D deficiency appears to enhance both bone marrow adipogenesis and intramuscular adipose tissue impacting as reduced functionality in both skeletal tissues. Controversial findings on the role of 1,25(OH)D on skeletal muscle may relate to differences in vitamin D receptor expression throughout different stages of muscle cell differentiation. Prolonged vitamin D insufficiency in the elderly is associated with reductions in both bone mineral density and type 2 muscle fibers with the outcomes of skeletal fragility in combination with reduced muscle power, leading to increased risk of falls and fracture.

KW - Accidental Falls

KW - Aged

KW - Bone Density

KW - Bone Diseases, Metabolic

KW - Calcitriol

KW - Fractures, Bone

KW - Humans

KW - Muscle Fibers, Fast-Twitch

KW - Muscle Strength

KW - Muscle, Skeletal

KW - Sarcopenia

KW - Vitamin D Deficiency

U2 - 10.1007/s11914-014-0193-4

DO - 10.1007/s11914-014-0193-4

M3 - Article

C2 - 24488588

VL - 12

SP - 74

EP - 81

JO - Current osteoporosis reports

JF - Current osteoporosis reports

SN - 1544-2241

IS - 1

ER -

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