Vitamin D deficiency in first episode psychosis: A case-control study

Matthieu Crews, John Lally*, Poonam Gardner-Sood, Oliver Howes, Stefania Bonaccorso, Shubulade Smith, Robin M. Murray, Marta Di Forti, Fiona Gaughran

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Citations (Scopus)

Abstract

Background: Vitamin D deficiency is seen in a high proportion of people with established psychotic disorders, but it is not known if this is present at onset of the illness. We set out to examine vitamin D levels in people with their first episode of psychosis (FEP).

Method: We conducted a matched case-control study to examine vitamin D levels and rates of vitamin D deficiency in sixty nine patients presenting with their FEP and sixty nine controls matched for age, sex and ethnicity. Differences between groups were tested using student's-t tests, paired t-tests and odds ratios for further analysis.

Results: Vitamin D levels were significantly lower in cases than in controls (p <0.001). The odds ratio of being vitamin D deficient was 2.99 in the FEP group relative to the control group. There was no correlation between vitamin D levels and length of hospitalisation in the patient group (r = -0.027, p = 0.827).

Conclusions: We found higher rates of vitamin D deficiency in people with FEP compared to matched controls. Given that vitamin D is neuroprotective; that developmental vitamin D deficiency may be a risk factor for psychosis, and that incipient psychosis may affect lifestyle factors and diet, future studies are required to examine this association further. In the meantime, there is a need for more widespread testing of vitamin D levels in FEP and for the development of appropriate management strategies.

Original languageEnglish
Pages (from-to)533-537
Number of pages5
JournalSchizophrenia Research
Volume150
Issue number2-3
DOIs
Publication statusPublished - Nov 2013

Keywords

  • First episode psychosis
  • Schizophrenia
  • 25-Hydroxyvitamin D
  • Vitamin D deficiency
  • Case-control study
  • Ethnicity
  • MULTIPLE HEALTH OUTCOMES
  • CARDIOVASCULAR-DISEASE
  • HYPOVITAMINOSIS-D
  • D INSUFFICIENCY
  • SCHIZOPHRENIA
  • RISK
  • POPULATION
  • 25-HYDROXYVITAMIN-D
  • SMOKING
  • DIETARY
  • Acknowledged-BRC
  • Acknowledged-BRC-13/14

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