Volumetric neural correlates of antisaccade eye movements in first-episode psychosis

U Ettinger; V Kumari; X A Chitnis; P J Corr; T J Crawford; D G Fannon; S O'Ceallaigh; A L Sumich; V C Doku; T Sharma

doi:10.1176/appi.ajp.161.10.1918

Volumetric neural correlates of antisaccade eye movements in first-episode psychosis

U Ettinger, V Kumari, X A Chitnis, P J Corr, T J Crawford, D G Fannon, S O'Ceallaigh, A L Sumich, V C Doku, T Sharma

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective: The authors investigated the structural brain correlates of antisaccade performance. Method: Magnetic resonance imaging was used to measure the volumes of the prefrontal, premotor, sensorimotor, and occipitoparietal cortices as well as the caudate, thalamus, cerebellar vermis, and cerebrum in 20 first-episode psychosis patients and 18 healthy comparison subjects. Antisaccades were recorded by using infrared oculography. Results: Groups significantly differed in terms of antisaccade error rate and amplitude gain and tended to differ in terms of latency but not brain region volumes. Premotor cortex volume predicted antisaccade error rate among comparison subjects. In the patient group, caudate volume was related to latency and amplitude gain. Negative symptoms, independent of structural volumes, predicted error rate. Conclusions: These findings point to altered structure-function relationships in first-episode psychosis.

Original language	English
Pages (from-to)	1918 - 1921
Number of pages	4
Journal	The American Journal of Psychiatry
Volume	161
Issue number	10
DOIs	https://doi.org/10.1176/appi.ajp.161.10.1918
Publication status	Published - Oct 2004

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10.1176/appi.ajp.161.10.1918

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title = "Volumetric neural correlates of antisaccade eye movements in first-episode psychosis",

abstract = "Objective: The authors investigated the structural brain correlates of antisaccade performance. Method: Magnetic resonance imaging was used to measure the volumes of the prefrontal, premotor, sensorimotor, and occipitoparietal cortices as well as the caudate, thalamus, cerebellar vermis, and cerebrum in 20 first-episode psychosis patients and 18 healthy comparison subjects. Antisaccades were recorded by using infrared oculography. Results: Groups significantly differed in terms of antisaccade error rate and amplitude gain and tended to differ in terms of latency but not brain region volumes. Premotor cortex volume predicted antisaccade error rate among comparison subjects. In the patient group, caudate volume was related to latency and amplitude gain. Negative symptoms, independent of structural volumes, predicted error rate. Conclusions: These findings point to altered structure-function relationships in first-episode psychosis.",

author = "U Ettinger and V Kumari and Chitnis, {X A} and Corr, {P J} and Crawford, {T J} and Fannon, {D G} and S O'Ceallaigh and Sumich, {A L} and Doku, {V C} and T Sharma",

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doi = "10.1176/appi.ajp.161.10.1918",

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AU - Ettinger, U

AU - Kumari, V

AU - Chitnis, X A

AU - Corr, P J

AU - Crawford, T J

AU - Fannon, D G

AU - O'Ceallaigh, S

AU - Sumich, A L

AU - Doku, V C

AU - Sharma, T

PY - 2004/10

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N2 - Objective: The authors investigated the structural brain correlates of antisaccade performance. Method: Magnetic resonance imaging was used to measure the volumes of the prefrontal, premotor, sensorimotor, and occipitoparietal cortices as well as the caudate, thalamus, cerebellar vermis, and cerebrum in 20 first-episode psychosis patients and 18 healthy comparison subjects. Antisaccades were recorded by using infrared oculography. Results: Groups significantly differed in terms of antisaccade error rate and amplitude gain and tended to differ in terms of latency but not brain region volumes. Premotor cortex volume predicted antisaccade error rate among comparison subjects. In the patient group, caudate volume was related to latency and amplitude gain. Negative symptoms, independent of structural volumes, predicted error rate. Conclusions: These findings point to altered structure-function relationships in first-episode psychosis.

AB - Objective: The authors investigated the structural brain correlates of antisaccade performance. Method: Magnetic resonance imaging was used to measure the volumes of the prefrontal, premotor, sensorimotor, and occipitoparietal cortices as well as the caudate, thalamus, cerebellar vermis, and cerebrum in 20 first-episode psychosis patients and 18 healthy comparison subjects. Antisaccades were recorded by using infrared oculography. Results: Groups significantly differed in terms of antisaccade error rate and amplitude gain and tended to differ in terms of latency but not brain region volumes. Premotor cortex volume predicted antisaccade error rate among comparison subjects. In the patient group, caudate volume was related to latency and amplitude gain. Negative symptoms, independent of structural volumes, predicted error rate. Conclusions: These findings point to altered structure-function relationships in first-episode psychosis.

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Volumetric neural correlates of antisaccade eye movements in first-episode psychosis

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