Von Willebrand factor - two sides and the edge of a coin

S. Rangarajan*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    Von Willebrand factor (VWF) has multiple functions in coagulation. It is a clotting protein and its deficiency causes a primary haemostatic bleeding disorder. Excess VWF, particularly high molecular weight multimers can cause thrombosis. There is also a debatable function of protecting factor VIII (FVIII) in circulation with the prevention of development of FVIII inhibitors. This commentary addresses these functions.
    Original languageEnglish
    Pages (from-to)61-64
    Number of pages4
    JournalHAEMOPHILIA
    Volume17
    Issue number1
    DOIs
    Publication statusPublished - Jan 2011

    Keywords

    • bleeding
    • thrombosis
    • factor VIII inhibitors
    • ADAMTS13
    • laboratory measurements
    • RECOMBINANT FACTOR-VIII
    • PREVIOUSLY UNTREATED PATIENTS
    • HEMOPHILIA-A
    • DOMAIN
    • EFFICACY
    • SAFETY
    • CONFORMATION
    • MICROSCOPY
    • DISEASE
    • RISK

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