Voxel based morphometric and diffusion tensor imaging analysis in male bipolar patients with first-episode mania

TY - JOUR

T1 - Voxel based morphometric and diffusion tensor imaging analysis in male bipolar patients with first-episode mania

AU - Chen, Zhuangfei

AU - Cui, Liqian

AU - Li, Mingli

AU - Jiang, Lijun

AU - Deng, Wei

AU - Ma, Xiaohong

AU - Wang, Qiang

AU - Huang, Chaohua

AU - Wang, Yingcheng

AU - Collier, David A.

AU - Gong, Qiyong

AU - Li, Tao

PY - 2012/3/30

Y1 - 2012/3/30

N2 - Objectives: Structural abnormality of both gray and white matter has been detected in patients with bipolar disorder (BD). But results were greatly inconsistent across studies which were most likely attributed to heterogeneous populations as well as processing techniques. The present study aimed to investigate brain structural and microstructural alterations in a relative homogenous sample of bipolar mania. Methods: 3D T1-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) were conducted in 18 patients with BD and 27 healthy volunteers. Gray matter (GM) and white matter (WM) differences were evaluated using voxel-based morphometry (VBM) and voxel-based analysis of fractional anisotropy (FA) maps derived from DTI, respectively. Results: Patients with BD had a larger volume of GM in the left thalamus and bilateral basal ganglia, including the bilateral putamen and extending to the left claustrum, as well as reduced FA values in the left posterior corona radiata. Conclusions: By combined analysis, alterations in subcortical GM areas and part of the corresponding association fiber area were detected. Compared with observations in homogeneous samples, our findings indicate that disruption of the limbic network may be intrinsic to BD. (C) 2011 Elsevier Inc. All rights reserved.

AB - Objectives: Structural abnormality of both gray and white matter has been detected in patients with bipolar disorder (BD). But results were greatly inconsistent across studies which were most likely attributed to heterogeneous populations as well as processing techniques. The present study aimed to investigate brain structural and microstructural alterations in a relative homogenous sample of bipolar mania. Methods: 3D T1-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) were conducted in 18 patients with BD and 27 healthy volunteers. Gray matter (GM) and white matter (WM) differences were evaluated using voxel-based morphometry (VBM) and voxel-based analysis of fractional anisotropy (FA) maps derived from DTI, respectively. Results: Patients with BD had a larger volume of GM in the left thalamus and bilateral basal ganglia, including the bilateral putamen and extending to the left claustrum, as well as reduced FA values in the left posterior corona radiata. Conclusions: By combined analysis, alterations in subcortical GM areas and part of the corresponding association fiber area were detected. Compared with observations in homogeneous samples, our findings indicate that disruption of the limbic network may be intrinsic to BD. (C) 2011 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.pnpbp.2011.11.002

DO - 10.1016/j.pnpbp.2011.11.002

M3 - Literature review

VL - 36

SP - 231

EP - 238

JO - Progress in Neuro-Psychopharmacology & Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology & Biological Psychiatry

IS - 2

ER -