TY - JOUR
T1 - Waist circumference and cardiometabolic parameters in people of African/Caribbean ancestry with HIV in South London (CKD-AFRICA study
AU - Cechin, Laura
AU - Dominguez-Dominguez, Lourdes
AU - Campbell, Lucy
AU - Hamzah, Lisa
AU - Fox, Julie
AU - Vincent, Royce P.
AU - Dimitriadis, Georgios K.
AU - Goff, Louise
AU - Post, Frank A.
PY - 2024/6
Y1 - 2024/6
N2 - Background: There are no validated waist circumference (WC) cut-offs to define metabolic syndrome in Black people with HIV. Methods: Cross-sectional analyses within the CKD-AFRICA study. We used Pearson correlation coefficients and receiver operating characteristic (ROC) curves to describe the relationship between WC and cardiometabolic parameters including triglycerides, cholesterol, glucose, glycated haemoglobin (HbA1c), and homeostatic model assessment for insulin resistance (HOMA-IR), and to identify optimal WC cut-offs for each of these outcomes. Results: We included 383 participants (55% female, median age 52 years) with generally well controlled HIV. Female and male participants had similar WC (median 98 vs. 97 cm, p =.16). Generally weak correlations (r2 < 0.2) between WC and other cardiometabolic parameters were observed, with low (<0.7) areas under the ROC curves. The optimal WC cut-offs for constituents of the metabolic syndrome, HbA1c and HOMA-IR ranged from 92 to 101 cm in women and 89-98 cm in men, respectively; these cut-offs had variable sensitivity (52%–100%) and generally poor specificity (28%–72%). Conclusions: In this cohort of Black people with HIV, WC cut-offs for cardiometabolic risk factors in male participants were in line with the recommended value of 94 cm while in female participants they vastly exceeded the recommended 80 cm for white women.
AB - Background: There are no validated waist circumference (WC) cut-offs to define metabolic syndrome in Black people with HIV. Methods: Cross-sectional analyses within the CKD-AFRICA study. We used Pearson correlation coefficients and receiver operating characteristic (ROC) curves to describe the relationship between WC and cardiometabolic parameters including triglycerides, cholesterol, glucose, glycated haemoglobin (HbA1c), and homeostatic model assessment for insulin resistance (HOMA-IR), and to identify optimal WC cut-offs for each of these outcomes. Results: We included 383 participants (55% female, median age 52 years) with generally well controlled HIV. Female and male participants had similar WC (median 98 vs. 97 cm, p =.16). Generally weak correlations (r2 < 0.2) between WC and other cardiometabolic parameters were observed, with low (<0.7) areas under the ROC curves. The optimal WC cut-offs for constituents of the metabolic syndrome, HbA1c and HOMA-IR ranged from 92 to 101 cm in women and 89-98 cm in men, respectively; these cut-offs had variable sensitivity (52%–100%) and generally poor specificity (28%–72%). Conclusions: In this cohort of Black people with HIV, WC cut-offs for cardiometabolic risk factors in male participants were in line with the recommended value of 94 cm while in female participants they vastly exceeded the recommended 80 cm for white women.
KW - black ethnicity
KW - HIV
KW - insulin resistance
KW - Metabolic syndrome
KW - waist circumference
UR - http://www.scopus.com/inward/record.url?scp=85186393443&partnerID=8YFLogxK
U2 - 10.1177/09564624241233036
DO - 10.1177/09564624241233036
M3 - Article
C2 - 38377277
AN - SCOPUS:85186393443
SN - 0956-4624
VL - 35
SP - 521
EP - 526
JO - International Journal of STD & AIDS
JF - International Journal of STD & AIDS
IS - 7
ER -