Wave speed in human coronary arteries is not influenced by microvascular vasodilation: implications for wave intensity analysis

M. Cristina Rolandi, Kalpa De Silva, Matthew Lumley, Timothy P. E. Lockie, Brian Clapp, Jos A. E. Spaan, Divaka Perera, Maria Siebes

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Wave intensity analysis and wave separation are powerful tools for interrogating coronary, myocardial and microvascular physiology. Wave speed is integral to these calculations and is usually estimated by the single-point technique (SPc), a feasible but as yet unvalidated approach in coronary vessels. We aimed to directly measure wave speed in human coronary arteries and assess the impact of adenosine and nitrate administration. In 14 patients, the transit time Δt between two pressure signals was measured in angiographically normal coronary arteries using a microcatheter equipped with two high-fidelity pressure sensors located Δs = 5 cm apart. Simultaneously, intracoronary pressure and flow velocity were measured with a dual-sensor wire to derive SPc. Actual wave speed was calculated as DNc = Δs/Δt. Hemodynamic signals were recorded at baseline and during adenosine-induced hyperemia, before and after nitroglycerin administration. The energy of separated wave intensity components was assessed using SPc and DNc. At baseline, DNc equaled SPc (15.9 ± 1.8 vs. 16.6 ± 1.5 m/s). Adenosine-induced hyperemia lowered SPc by 40 % (p 
Original languageEnglish
JournalBasic Research in Cardiology
Volume109
Issue number2
Early online date11 Feb 2014
DOIs
Publication statusPublished - 2014

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