Wavelength-orthogonal photolysis of neurotransmitters in vitro

Megan N Stanton-Humphreys; Ruth D T Taylor; Craig McDougall; Mike L Hart; C Tom A Brown; Nigel J Emptage; Stuart J Conway

doi:10.1039/c1cc15135e

Wavelength-orthogonal photolysis of neurotransmitters in vitro

Megan N Stanton-Humphreys, Ruth D T Taylor, Craig McDougall, Mike L Hart, C Tom A Brown, Nigel J Emptage, Stuart J Conway

Developmental Neurobiology

University of Oxford

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Irradiation of a mixture of 4-methoxyphenacyl-caged (S)-glutamate and 4,5-dimethoxy-2-nitrobenzyl-caged γ-amino butyric acid (GABA) on neurons, at ~260 nm, evokes selective photorelease of (S)-glutamate (Glu) whereas photolysis at 405 nm causes selective photorelease of GABA.

Original language	English
Pages (from-to)	657-9
Number of pages	3
Journal	Chemical communications (Cambridge, England)
Volume	48
Issue number	5
DOIs	https://doi.org/10.1039/c1cc15135e
Publication status	Published - 18 Jan 2012

Keywords

Animals
Excitatory Amino Acid Antagonists
GABA Antagonists
Glutamates
Hippocampus
Magnetic Resonance Spectroscopy
Neurons
Neurotransmitter Agents
Patch-Clamp Techniques
Photochemistry
Photolysis
Receptors, GABA
Receptors, Glutamate
Synaptic Transmission
Ultraviolet Rays
gamma-Aminobutyric Acid
Journal Article
Research Support, Non-U.S. Gov't

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10.1039/c1cc15135e

Cite this

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title = "Wavelength-orthogonal photolysis of neurotransmitters in vitro",

abstract = "Irradiation of a mixture of 4-methoxyphenacyl-caged (S)-glutamate and 4,5-dimethoxy-2-nitrobenzyl-caged γ-amino butyric acid (GABA) on neurons, at ~260 nm, evokes selective photorelease of (S)-glutamate (Glu) whereas photolysis at 405 nm causes selective photorelease of GABA.",

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AU - Stanton-Humphreys, Megan N

AU - Taylor, Ruth D T

AU - McDougall, Craig

AU - Hart, Mike L

AU - Brown, C Tom A

AU - Emptage, Nigel J

AU - Conway, Stuart J

PY - 2012/1/18

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N2 - Irradiation of a mixture of 4-methoxyphenacyl-caged (S)-glutamate and 4,5-dimethoxy-2-nitrobenzyl-caged γ-amino butyric acid (GABA) on neurons, at ~260 nm, evokes selective photorelease of (S)-glutamate (Glu) whereas photolysis at 405 nm causes selective photorelease of GABA.

AB - Irradiation of a mixture of 4-methoxyphenacyl-caged (S)-glutamate and 4,5-dimethoxy-2-nitrobenzyl-caged γ-amino butyric acid (GABA) on neurons, at ~260 nm, evokes selective photorelease of (S)-glutamate (Glu) whereas photolysis at 405 nm causes selective photorelease of GABA.

KW - Animals

KW - Excitatory Amino Acid Antagonists

KW - GABA Antagonists

KW - Glutamates

KW - Hippocampus

KW - Magnetic Resonance Spectroscopy

KW - Neurons

KW - Neurotransmitter Agents

KW - Patch-Clamp Techniques

KW - Photochemistry

KW - Photolysis

KW - Receptors, GABA

KW - Receptors, Glutamate

KW - Synaptic Transmission

KW - Ultraviolet Rays

KW - gamma-Aminobutyric Acid

KW - Journal Article

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DO - 10.1039/c1cc15135e

M3 - Article

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JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

IS - 5

ER -

Wavelength-orthogonal photolysis of neurotransmitters in vitro

Abstract

Keywords

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