Wavelength-orthogonal photolysis of neurotransmitters in vitro

Megan N Stanton-Humphreys, Ruth D T Taylor, Craig McDougall, Mike L Hart, C Tom A Brown, Nigel J Emptage, Stuart J Conway

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Irradiation of a mixture of 4-methoxyphenacyl-caged (S)-glutamate and 4,5-dimethoxy-2-nitrobenzyl-caged γ-amino butyric acid (GABA) on neurons, at ~260 nm, evokes selective photorelease of (S)-glutamate (Glu) whereas photolysis at 405 nm causes selective photorelease of GABA.

Original languageEnglish
Pages (from-to)657-9
Number of pages3
JournalChemical communications (Cambridge, England)
Volume48
Issue number5
DOIs
Publication statusPublished - 18 Jan 2012

Keywords

  • Animals
  • Excitatory Amino Acid Antagonists
  • GABA Antagonists
  • Glutamates
  • Hippocampus
  • Magnetic Resonance Spectroscopy
  • Neurons
  • Neurotransmitter Agents
  • Patch-Clamp Techniques
  • Photochemistry
  • Photolysis
  • Receptors, GABA
  • Receptors, Glutamate
  • Synaptic Transmission
  • Ultraviolet Rays
  • gamma-Aminobutyric Acid
  • Journal Article
  • Research Support, Non-U.S. Gov't

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