TY - JOUR
T1 - Weekly Supervised Administration of Oral Antipsychotics
T2 - An Alternative to Long-Acting Injections?
AU - Brissos, Sofia
AU - Taylor, David
N1 - Funding Information:
S.B. was Medical Affairs Manager for Janssen Portugal from 2010 to 2013. She has received honoraria for lectures, podcasts, advisory boards, educational videos and travel expenses from Janssen, Lundbeck, Otsuka, Jaba Recordati and Angelini in the last 3 years. D.T. has received speaker honoraria and research funding from Janssen, Recordati and Sunovion and is currently receiving a grant (#1126389) from Janssen UK.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2022/2/28
Y1 - 2022/2/28
N2 - Maintenance of response in schizophrenia is largely dependent on compliance with antipsychotic treatment. When people with schizophrenia are responsible for their own treatment, partial or non-adherence is common and usually results in relapse. Assured compliance with antipsychotic treatment is possible when long-acting injectable antipsychotics are given by healthcare staff, but some patients may not consent to treatment for a variety of reasons. An alternative to long-acting injections is the use of supervised oral administration of long-acting antipsychotics. This method assures compliance with prescribed regimens without the need for injections. To be suitable for once-weekly administration as an oral formulation, an antipsychotic needs to have a sufficiently long duration of action and to be well tolerated in high doses. There is evidence that weekly oral administration of either pimozide or penfluridol is effective and well tolerated in the treatment of schizophrenia. Other drugs potentially suitable for once-weekly oral administration include aripiprazole, brexpiprazole and cariprazine.
AB - Maintenance of response in schizophrenia is largely dependent on compliance with antipsychotic treatment. When people with schizophrenia are responsible for their own treatment, partial or non-adherence is common and usually results in relapse. Assured compliance with antipsychotic treatment is possible when long-acting injectable antipsychotics are given by healthcare staff, but some patients may not consent to treatment for a variety of reasons. An alternative to long-acting injections is the use of supervised oral administration of long-acting antipsychotics. This method assures compliance with prescribed regimens without the need for injections. To be suitable for once-weekly administration as an oral formulation, an antipsychotic needs to have a sufficiently long duration of action and to be well tolerated in high doses. There is evidence that weekly oral administration of either pimozide or penfluridol is effective and well tolerated in the treatment of schizophrenia. Other drugs potentially suitable for once-weekly oral administration include aripiprazole, brexpiprazole and cariprazine.
UR - http://www.scopus.com/inward/record.url?scp=85125426254&partnerID=8YFLogxK
U2 - 10.1007/s40263-022-00906-4
DO - 10.1007/s40263-022-00906-4
M3 - Article
C2 - 35226350
AN - SCOPUS:85125426254
SN - 1172-7047
VL - 36
SP - 315
EP - 325
JO - CNS Drugs
JF - CNS Drugs
IS - 4
ER -
