Weekly Supervised Administration of Oral Antipsychotics: An Alternative to Long-Acting Injections?

Sofia Brissos; David Taylor

doi:10.1007/s40263-022-00906-4

Weekly Supervised Administration of Oral Antipsychotics: An Alternative to Long-Acting Injections?

Sofia Brissos, David Taylor^*

^*Corresponding author for this work

Institute of Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Maintenance of response in schizophrenia is largely dependent on compliance with antipsychotic treatment. When people with schizophrenia are responsible for their own treatment, partial or non-adherence is common and usually results in relapse. Assured compliance with antipsychotic treatment is possible when long-acting injectable antipsychotics are given by healthcare staff, but some patients may not consent to treatment for a variety of reasons. An alternative to long-acting injections is the use of supervised oral administration of long-acting antipsychotics. This method assures compliance with prescribed regimens without the need for injections. To be suitable for once-weekly administration as an oral formulation, an antipsychotic needs to have a sufficiently long duration of action and to be well tolerated in high doses. There is evidence that weekly oral administration of either pimozide or penfluridol is effective and well tolerated in the treatment of schizophrenia. Other drugs potentially suitable for once-weekly oral administration include aripiprazole, brexpiprazole and cariprazine.

Original language	English
Pages (from-to)	315-325
Number of pages	11
Journal	CNS Drugs
Volume	36
Issue number	4
DOIs	https://doi.org/10.1007/s40263-022-00906-4
Publication status	Published - 28 Feb 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s40263-022-00906-4

Cite this

@article{2288d2bb5e1148f09e0a80a71ab60b2b,

title = "Weekly Supervised Administration of Oral Antipsychotics: An Alternative to Long-Acting Injections?",

abstract = "Maintenance of response in schizophrenia is largely dependent on compliance with antipsychotic treatment. When people with schizophrenia are responsible for their own treatment, partial or non-adherence is common and usually results in relapse. Assured compliance with antipsychotic treatment is possible when long-acting injectable antipsychotics are given by healthcare staff, but some patients may not consent to treatment for a variety of reasons. An alternative to long-acting injections is the use of supervised oral administration of long-acting antipsychotics. This method assures compliance with prescribed regimens without the need for injections. To be suitable for once-weekly administration as an oral formulation, an antipsychotic needs to have a sufficiently long duration of action and to be well tolerated in high doses. There is evidence that weekly oral administration of either pimozide or penfluridol is effective and well tolerated in the treatment of schizophrenia. Other drugs potentially suitable for once-weekly oral administration include aripiprazole, brexpiprazole and cariprazine.",

author = "Sofia Brissos and David Taylor",

note = "Funding Information: S.B. was Medical Affairs Manager for Janssen Portugal from 2010 to 2013. She has received honoraria for lectures, podcasts, advisory boards, educational videos and travel expenses from Janssen, Lundbeck, Otsuka, Jaba Recordati and Angelini in the last 3 years. D.T. has received speaker honoraria and research funding from Janssen, Recordati and Sunovion and is currently receiving a grant (#1126389) from Janssen UK. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.",

year = "2022",

month = feb,

day = "28",

doi = "10.1007/s40263-022-00906-4",

language = "English",

volume = "36",

pages = "315--325",

journal = "CNS Drugs",

issn = "1172-7047",

publisher = "Adis International Ltd",

number = "4",

}

TY - JOUR

T1 - Weekly Supervised Administration of Oral Antipsychotics

T2 - An Alternative to Long-Acting Injections?

AU - Brissos, Sofia

AU - Taylor, David

N1 - Funding Information: S.B. was Medical Affairs Manager for Janssen Portugal from 2010 to 2013. She has received honoraria for lectures, podcasts, advisory boards, educational videos and travel expenses from Janssen, Lundbeck, Otsuka, Jaba Recordati and Angelini in the last 3 years. D.T. has received speaker honoraria and research funding from Janssen, Recordati and Sunovion and is currently receiving a grant (#1126389) from Janssen UK. Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.

PY - 2022/2/28

Y1 - 2022/2/28

N2 - Maintenance of response in schizophrenia is largely dependent on compliance with antipsychotic treatment. When people with schizophrenia are responsible for their own treatment, partial or non-adherence is common and usually results in relapse. Assured compliance with antipsychotic treatment is possible when long-acting injectable antipsychotics are given by healthcare staff, but some patients may not consent to treatment for a variety of reasons. An alternative to long-acting injections is the use of supervised oral administration of long-acting antipsychotics. This method assures compliance with prescribed regimens without the need for injections. To be suitable for once-weekly administration as an oral formulation, an antipsychotic needs to have a sufficiently long duration of action and to be well tolerated in high doses. There is evidence that weekly oral administration of either pimozide or penfluridol is effective and well tolerated in the treatment of schizophrenia. Other drugs potentially suitable for once-weekly oral administration include aripiprazole, brexpiprazole and cariprazine.

AB - Maintenance of response in schizophrenia is largely dependent on compliance with antipsychotic treatment. When people with schizophrenia are responsible for their own treatment, partial or non-adherence is common and usually results in relapse. Assured compliance with antipsychotic treatment is possible when long-acting injectable antipsychotics are given by healthcare staff, but some patients may not consent to treatment for a variety of reasons. An alternative to long-acting injections is the use of supervised oral administration of long-acting antipsychotics. This method assures compliance with prescribed regimens without the need for injections. To be suitable for once-weekly administration as an oral formulation, an antipsychotic needs to have a sufficiently long duration of action and to be well tolerated in high doses. There is evidence that weekly oral administration of either pimozide or penfluridol is effective and well tolerated in the treatment of schizophrenia. Other drugs potentially suitable for once-weekly oral administration include aripiprazole, brexpiprazole and cariprazine.

UR - http://www.scopus.com/inward/record.url?scp=85125426254&partnerID=8YFLogxK

U2 - 10.1007/s40263-022-00906-4

DO - 10.1007/s40263-022-00906-4

M3 - Article

C2 - 35226350

AN - SCOPUS:85125426254

SN - 1172-7047

VL - 36

SP - 315

EP - 325

JO - CNS Drugs

JF - CNS Drugs

IS - 4

ER -

Weekly Supervised Administration of Oral Antipsychotics: An Alternative to Long-Acting Injections?

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this