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What are we targeting when we treat autism spectrum disorder? A systematic review of 406 clinical trials

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What are we targeting when we treat autism spectrum disorder? A systematic review of 406 clinical trials. / Provenzani, Umberto; Fusar-Poli, Laura; Brondino, Natascia; Damiani, Stefano; Vercesi, Marco; Meyer, Nicholas; Rocchetti, Matteo; Politi, Pierluigi.

In: Autism, Vol. 24, No. 2, 01.02.2020, p. 274-284.

Research output: Contribution to journalReview article

Harvard

Provenzani, U, Fusar-Poli, L, Brondino, N, Damiani, S, Vercesi, M, Meyer, N, Rocchetti, M & Politi, P 2020, 'What are we targeting when we treat autism spectrum disorder? A systematic review of 406 clinical trials', Autism, vol. 24, no. 2, pp. 274-284. https://doi.org/10.1177/1362361319854641

APA

Provenzani, U., Fusar-Poli, L., Brondino, N., Damiani, S., Vercesi, M., Meyer, N., Rocchetti, M., & Politi, P. (2020). What are we targeting when we treat autism spectrum disorder? A systematic review of 406 clinical trials. Autism, 24(2), 274-284. https://doi.org/10.1177/1362361319854641

Vancouver

Provenzani U, Fusar-Poli L, Brondino N, Damiani S, Vercesi M, Meyer N et al. What are we targeting when we treat autism spectrum disorder? A systematic review of 406 clinical trials. Autism. 2020 Feb 1;24(2):274-284. https://doi.org/10.1177/1362361319854641

Author

Provenzani, Umberto ; Fusar-Poli, Laura ; Brondino, Natascia ; Damiani, Stefano ; Vercesi, Marco ; Meyer, Nicholas ; Rocchetti, Matteo ; Politi, Pierluigi. / What are we targeting when we treat autism spectrum disorder? A systematic review of 406 clinical trials. In: Autism. 2020 ; Vol. 24, No. 2. pp. 274-284.

Bibtex Download

@article{31741e1055d24275aababa402566f97e,
title = "What are we targeting when we treat autism spectrum disorder?: A systematic review of 406 clinical trials",
abstract = "The number of trials aimed at evaluating treatments for autism spectrum disorder has been increasing progressively. However, it is not clear which outcome measures should be used to assess their efficacy, especially for treatments which target core symptoms. The present review aimed to provide a comprehensive overview regarding the outcome measures used in clinical trials for people with autism spectrum disorder. We systematically searched the Web of KnowledgeSM database between 1980 and 2016 to identify published controlled trials investigating the efficacy of interventions in autism spectrum disorder. We included 406 trials in the final database, from which a total of 327 outcome measures were identified. Only seven scales were used in more than 5% of the studies, among which only three measured core symptoms (Autism Diagnostic Observation Schedule, Childhood Autism Rating Scale, and Social Responsiveness Scale). Of note, 69% of the tools were used in the literature only once. Our systematic review has shown that the evaluation of efficacy in intervention trials for autism spectrum disorder relies on heterogeneous and often non-specific tools for this condition. The fragmentation of tools may significantly hamper the comparisons between studies and thus the discovery of effective treatments for autism spectrum disorder. Greater consensus regarding the choice of these measures should be reached.",
keywords = "autism spectrum disorder, core symptoms, outcome measures, systematic review, trials",
author = "Umberto Provenzani and Laura Fusar-Poli and Natascia Brondino and Stefano Damiani and Marco Vercesi and Nicholas Meyer and Matteo Rocchetti and Pierluigi Politi",
year = "2020",
month = feb,
day = "1",
doi = "10.1177/1362361319854641",
language = "English",
volume = "24",
pages = "274--284",
journal = "Autism",
issn = "1362-3613",
publisher = "SAGE Publications Ltd",
number = "2",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - What are we targeting when we treat autism spectrum disorder?

T2 - A systematic review of 406 clinical trials

AU - Provenzani, Umberto

AU - Fusar-Poli, Laura

AU - Brondino, Natascia

AU - Damiani, Stefano

AU - Vercesi, Marco

AU - Meyer, Nicholas

AU - Rocchetti, Matteo

AU - Politi, Pierluigi

PY - 2020/2/1

Y1 - 2020/2/1

N2 - The number of trials aimed at evaluating treatments for autism spectrum disorder has been increasing progressively. However, it is not clear which outcome measures should be used to assess their efficacy, especially for treatments which target core symptoms. The present review aimed to provide a comprehensive overview regarding the outcome measures used in clinical trials for people with autism spectrum disorder. We systematically searched the Web of KnowledgeSM database between 1980 and 2016 to identify published controlled trials investigating the efficacy of interventions in autism spectrum disorder. We included 406 trials in the final database, from which a total of 327 outcome measures were identified. Only seven scales were used in more than 5% of the studies, among which only three measured core symptoms (Autism Diagnostic Observation Schedule, Childhood Autism Rating Scale, and Social Responsiveness Scale). Of note, 69% of the tools were used in the literature only once. Our systematic review has shown that the evaluation of efficacy in intervention trials for autism spectrum disorder relies on heterogeneous and often non-specific tools for this condition. The fragmentation of tools may significantly hamper the comparisons between studies and thus the discovery of effective treatments for autism spectrum disorder. Greater consensus regarding the choice of these measures should be reached.

AB - The number of trials aimed at evaluating treatments for autism spectrum disorder has been increasing progressively. However, it is not clear which outcome measures should be used to assess their efficacy, especially for treatments which target core symptoms. The present review aimed to provide a comprehensive overview regarding the outcome measures used in clinical trials for people with autism spectrum disorder. We systematically searched the Web of KnowledgeSM database between 1980 and 2016 to identify published controlled trials investigating the efficacy of interventions in autism spectrum disorder. We included 406 trials in the final database, from which a total of 327 outcome measures were identified. Only seven scales were used in more than 5% of the studies, among which only three measured core symptoms (Autism Diagnostic Observation Schedule, Childhood Autism Rating Scale, and Social Responsiveness Scale). Of note, 69% of the tools were used in the literature only once. Our systematic review has shown that the evaluation of efficacy in intervention trials for autism spectrum disorder relies on heterogeneous and often non-specific tools for this condition. The fragmentation of tools may significantly hamper the comparisons between studies and thus the discovery of effective treatments for autism spectrum disorder. Greater consensus regarding the choice of these measures should be reached.

KW - autism spectrum disorder

KW - core symptoms

KW - outcome measures

KW - systematic review

KW - trials

UR - http://www.scopus.com/inward/record.url?scp=85068589323&partnerID=8YFLogxK

U2 - 10.1177/1362361319854641

DO - 10.1177/1362361319854641

M3 - Review article

C2 - 31269800

VL - 24

SP - 274

EP - 284

JO - Autism

JF - Autism

SN - 1362-3613

IS - 2

ER -

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