Research output: Contribution to journal › Article › peer-review
Original language | English |
---|---|
Pages (from-to) | 275-283 |
Number of pages | 9 |
Journal | Current transplantation reports |
Volume | 3 |
Issue number | 4 |
DOIs | |
E-pub ahead of print | 7 Oct 2016 |
What is direct Allorecognition_BOARDMAN_Firstonline7October2016_GOLD VoR
What_is_direct_Allorecognition_BOARDMAN_Firstonline7October2016_GOLD_VoR.pdf, 677 KB, application/pdf
Uploaded date:21 Dec 2016
Version:Final published version
Licence:CC BY
Direct allorecognition is the process by which donor-derived major histocompatibility complex (MHC)-peptide complexes, typically presented by donor-derived 'passenger' dendritic cells, are recognised directly by recipient T cells. In this review, we discuss the two principle theories which have been proposed to explain why individuals possess a high-precursor frequency of T cells with direct allospecificity and how self-restricted T cells recognise allogeneic MHC-peptide complexes. These theories, both of which are supported by functional and structural data, suggest that T cells recognising allogeneic MHC-peptide complexes focus either on the allopeptides bound to the allo-MHC molecules or the allo-MHC molecules themselves. We discuss how direct alloimmune responses may be sustained long term, the consequences of this for graft outcome and highlight novel strategies which are currently being investigated as a potential means of reducing rejection mediated through this pathway.
King's College London - Homepage
© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454