Research output: Contribution to journal › Article › peer-review
Original language | English |
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Journal | Acta Obstetricia et Gynecologica Scandinavica |
Early online date | 7 Feb 2017 |
DOIs | |
Accepted/In press | 31 Jan 2017 |
E-pub ahead of print | 7 Feb 2017 |
Additional links |
What is the impact of preconception_Vousden_Accepted 31January2017 GREEN AAM
What_is_the_impact_of_preconception_Vousden_Accepted_31January2017_GREEN_AAM.pdf, 145 KB, application/pdf
Uploaded date:21 Feb 2017
Version:Accepted author manuscript
Introduction: There is documented concern that cerclage may cause cervical stenosis or changes to the cervical mucus, which may reduce fertility. The aim of this study is to determine whether placement of a preconception abdominal cerclage affects fertility. Material and methods: This was a planned subgroup analysis of a randomized controlled trial comparing abdominal cerclage, high vaginal cerclage or low vaginal cerclage. Women with a history of previous second-trimester miscarriage or preterm birth despite having a low vaginal cerclage, presenting to specialist preterm birth services in the UK, were eligible for inclusion. Only women randomized before conception were included in this analysis. Women randomized to abdominal cerclage had the surgery performed before conception (abdominal group). Women randomized to high or low transvaginal cerclage received it in the subsequent pregnancy (control group). Results: Abdominal cerclage was performed in 19 women and transvaginal cerclage in 48 women. Overall, there was no statistically significant difference between time to conception between the two groups (hazard ratio 1.34; 95% confidence interval 0.72-2.50, p = 0.35). Rates of conception at 6, 12, and 18 months were similar - 37% in abdominal group vs. 35% in control group at 6 months (relative risk 1.04; 95% confidence interval 0.52-2.10; p = 0.91); 58% in abdominal group vs. 42% in control group at 12 months (relative risk 1.39; 95% confidence interval 0.84-2.31, p = 0.21); 74% in abdominal group vs. 56% in control group at 18 months (relative risk 1.31; 95% confidence interval 0.91-1.89; p = 0.15). Conclusion: This subgroup analysis of randomized data indicates that abdominal cerclage does not affect fertility rates.
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