What is the mechanism whereby cannabis use increases risk of psychosis?

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

Cannabis use has increased greatly over the last three decades. The various types of cannabis differ in their concentration of the main psychoactive component, Delta-9-tetrahydrocannabinol (THC), and the other major ingredient, cannabidiol (CBD). Plant engineering has maximized levels of THC, thus increasing the potency of street cannabis. It is well known that cannabis intoxication can cause brief psychotic symptoms like paranoia, whilst recent evidence demonstrates that heavy use of cannabis increases the risk of chronic psychoses like schizophrenia; genetic vulnerability seems to predispose some people to a higher risk. This paper starts to consider the neurochemical mechanisms whereby cannabis use increases the risk of psychosis.
Original languageEnglish
Pages (from-to)105 - 112
Number of pages8
JournalNEUROTOXICITY RESEARCH
Volume14
Issue number2-3
DOIs
Publication statusPublished - Jun 2008

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