When and how does BDNF activate Nrf2 in astrocytes and neurons?

TY - JOUR

T1 - When and how does BDNF activate Nrf2 in astrocytes and neurons?

AU - Ishii, Tetsuro

AU - Mann, Giovanni Enrico

PY - 2018

Y1 - 2018

N2 - Circadian rhythm dysfunction is often observed in patients with Alzheimer’s, Parkinson’s and Huntington disease. Clinical studies and experiments in animal models of neurodegenerative disorders have revealed the progressive nature of circadian dysfunction throughout the course of neurodegeneration. However, the importance of circadian rhythm in the protection of neurons remains to be elucidated. Recent studies suggest that disruption of the circadian rhythm can impair metabolic cooperation between neurons and astrocytes, and thereby enhance oxidative damages in the brain. Thus, understanding the molecular mechanisms by which endogenous antioxidant defense systems are controlled by the circadian rhythm may inform the design of novel therapeutic strategies to protect against neurodegenerative diseases. We recently proposed that neurotrophins activate the redox sensitive transcription factor Nrf2, a master regulator of cellular defense against oxidative stress, in a circadian rhythm dependent manner in astrocytes to support neurons in the brain.

AB - Circadian rhythm dysfunction is often observed in patients with Alzheimer’s, Parkinson’s and Huntington disease. Clinical studies and experiments in animal models of neurodegenerative disorders have revealed the progressive nature of circadian dysfunction throughout the course of neurodegeneration. However, the importance of circadian rhythm in the protection of neurons remains to be elucidated. Recent studies suggest that disruption of the circadian rhythm can impair metabolic cooperation between neurons and astrocytes, and thereby enhance oxidative damages in the brain. Thus, understanding the molecular mechanisms by which endogenous antioxidant defense systems are controlled by the circadian rhythm may inform the design of novel therapeutic strategies to protect against neurodegenerative diseases. We recently proposed that neurotrophins activate the redox sensitive transcription factor Nrf2, a master regulator of cellular defense against oxidative stress, in a circadian rhythm dependent manner in astrocytes to support neurons in the brain.

M3 - Article

SN - 1673-5374

JO - Neural regeneration research

JF - Neural regeneration research

ER -