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When and how does BDNF activate Nrf2 in astrocytes and neurons?

Research output: Contribution to journalArticle

Tetsuro Ishii, Giovanni Enrico Mann

Original languageEnglish
JournalNeural regeneration research
Accepted/In press3 Mar 2018

King's Authors


Circadian rhythm dysfunction is often observed in patients with Alzheimer’s, Parkinson’s and Huntington disease. Clinical studies and experiments in animal models of neurodegenerative disorders have revealed the progressive nature of circadian dysfunction throughout the course of neurodegeneration. However, the importance of circadian rhythm in the protection of neurons remains to be elucidated. Recent studies suggest that disruption of the circadian rhythm can impair metabolic cooperation between neurons and astrocytes, and thereby enhance oxidative damages in the brain. Thus, understanding the molecular mechanisms by which endogenous antioxidant defense systems are controlled by the circadian rhythm may inform the design of novel therapeutic strategies to protect against neurodegenerative diseases. We recently proposed that neurotrophins activate the redox sensitive transcription factor Nrf2, a master regulator of cellular defense against oxidative stress, in a circadian rhythm dependent manner in astrocytes to support neurons in the brain.

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