When change is the only constant: The promise of longitudinal neuroimaging in understanding social anxiety disorder

Simone P.W. Haller; Kathryn L. Mills; Charlotte E. Hartwright; Anthony S. David; Kathrin Cohen Kadosh

doi:10.1016/j.dcn.2018.05.005

When change is the only constant: The promise of longitudinal neuroimaging in understanding social anxiety disorder

Simone P.W. Haller, Kathryn L. Mills, Charlotte E. Hartwright, Anthony S. David, Kathrin Cohen Kadosh

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Abstract

Longitudinal studies offer a unique window into developmental change. Yet, most of what we know about the pathophysiology of psychiatric disorders is based on cross-sectional work. Here, we highlight the importance of adopting a longitudinal approach in order to make progress into the identification of neurobiological mechanisms of social anxiety disorder (SAD). Using examples, we illustrate how longitudinal data can uniquely inform SAD etiology and timing of interventions. The brain’s inherently adaptive quality requires that we model risk correlates of disorders as dynamic in their expression. Developmental theories regarding timing of environmental events, cascading effects and (mal)adaptations of the developing brain will be crucial components of comprehensive, integrative models of SAD. We close by discussing analytical considerations in working with longitudinal, developmental data.

Original language	English
Journal	Developmental Cognitive Neuroscience
DOIs	https://doi.org/10.1016/j.dcn.2018.05.005
Publication status	Accepted/In press - 23 May 2018

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When change is the only_HALLER_Accepted23May2018_GOLD AAMAccepted author manuscript, 490 KB

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title = "When change is the only constant: The promise of longitudinal neuroimaging in understanding social anxiety disorder",

abstract = "Longitudinal studies offer a unique window into developmental change. Yet, most of what we know about the pathophysiology of psychiatric disorders is based on cross-sectional work. Here, we highlight the importance of adopting a longitudinal approach in order to make progress into the identification of neurobiological mechanisms of social anxiety disorder (SAD). Using examples, we illustrate how longitudinal data can uniquely inform SAD etiology and timing of interventions. The brain{\textquoteright}s inherently adaptive quality requires that we model risk correlates of disorders as dynamic in their expression. Developmental theories regarding timing of environmental events, cascading effects and (mal)adaptations of the developing brain will be crucial components of comprehensive, integrative models of SAD. We close by discussing analytical considerations in working with longitudinal, developmental data.",

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AU - Mills, Kathryn L.

AU - Hartwright, Charlotte E.

AU - David, Anthony S.

AU - Kadosh, Kathrin Cohen

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AB - Longitudinal studies offer a unique window into developmental change. Yet, most of what we know about the pathophysiology of psychiatric disorders is based on cross-sectional work. Here, we highlight the importance of adopting a longitudinal approach in order to make progress into the identification of neurobiological mechanisms of social anxiety disorder (SAD). Using examples, we illustrate how longitudinal data can uniquely inform SAD etiology and timing of interventions. The brain’s inherently adaptive quality requires that we model risk correlates of disorders as dynamic in their expression. Developmental theories regarding timing of environmental events, cascading effects and (mal)adaptations of the developing brain will be crucial components of comprehensive, integrative models of SAD. We close by discussing analytical considerations in working with longitudinal, developmental data.

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JO - Developmental Cognitive Neuroscience

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When change is the only constant: The promise of longitudinal neuroimaging in understanding social anxiety disorder

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