Whole genome linkage scan of recurrent depressive disorder from the depression network study

P. McGuffin; J. Knight; G. Breen; S. Brewster; P. R. Boyd; N. Craddock; M. Gill; A. Korszun; W. Maier; L. Middleton; O. Mors; M. J. Owen; J. Perry; M. Preisig; T. Reich; J. Rice; M. Rietschel; L. Jones; P. Sham; A. E. Farmer

doi:10.1093/hmg/ddi363

Whole genome linkage scan of recurrent depressive disorder from the depression network study

P. McGuffin, J. Knight, G. Breen, S. Brewster, P. R. Boyd, N. Craddock, M. Gill, A. Korszun, W. Maier, L. Middleton, O. Mors, M. J. Owen, J. Perry, M. Preisig, T. Reich, J. Rice, M. Rietschel, L. Jones, P. Sham, A. E. Farmer

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Abstract

Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female-female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing). The region includes a gene, MTHFR, that in previous studies has been associated with depressive symptoms. Two other regions, on chromosomes 12q23.3-q24.11 and 13q31.1-q31.3, showed evidence for linkage with a nominal P <0.01. The 12q peak overlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and contains a gene, DAO, that has been associated with both bipolar disorder and schizophrenia. The 13q peak lies within a region previously linked strongly to panic disorder. A fourth modest peak with an LOD of greater than 1 on chromosome 15q lies within a region that showed genome-wide significant evidence of a recurrent depression locus in a previous sib-pair study. Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined.

Original language	English
Pages (from-to)	3337-3345
Number of pages	9
Journal	Human Molecular Genetics
Volume	14
Issue number	22
DOIs	https://doi.org/10.1093/hmg/ddi363
Publication status	Published - 15 Nov 2005

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McGuffin, P., Knight, J., Breen, G., Brewster, S., Boyd, P. R., Craddock, N., Gill, M., Korszun, A., Maier, W., Middleton, L., Mors, O., Owen, M. J., Perry, J., Preisig, M., Reich, T., Rice, J., Rietschel, M., Jones, L., Sham, P., & Farmer, A. E. (2005). Whole genome linkage scan of recurrent depressive disorder from the depression network study. Human Molecular Genetics, 14(22), 3337-3345. https://doi.org/10.1093/hmg/ddi363

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title = "Whole genome linkage scan of recurrent depressive disorder from the depression network study",

abstract = "Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female-female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing). The region includes a gene, MTHFR, that in previous studies has been associated with depressive symptoms. Two other regions, on chromosomes 12q23.3-q24.11 and 13q31.1-q31.3, showed evidence for linkage with a nominal P <0.01. The 12q peak overlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and contains a gene, DAO, that has been associated with both bipolar disorder and schizophrenia. The 13q peak lies within a region previously linked strongly to panic disorder. A fourth modest peak with an LOD of greater than 1 on chromosome 15q lies within a region that showed genome-wide significant evidence of a recurrent depression locus in a previous sib-pair study. Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined.",

author = "P. McGuffin and J. Knight and G. Breen and S. Brewster and Boyd, {P. R.} and N. Craddock and M. Gill and A. Korszun and W. Maier and L. Middleton and O. Mors and Owen, {M. J.} and J. Perry and M. Preisig and T. Reich and J. Rice and M. Rietschel and L. Jones and P. Sham and Farmer, {A. E.}",

year = "2005",

month = nov,

day = "15",

doi = "10.1093/hmg/ddi363",

language = "English",

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McGuffin, P , Knight, J , Breen, G, Brewster, S, Boyd, PR, Craddock, N, Gill, M, Korszun, A, Maier, W, Middleton, L, Mors, O, Owen, MJ, Perry, J, Preisig, M, Reich, T, Rice, J, Rietschel, M, Jones, L , Sham, P & Farmer, AE 2005, 'Whole genome linkage scan of recurrent depressive disorder from the depression network study', Human Molecular Genetics, vol. 14, no. 22, pp. 3337-3345. https://doi.org/10.1093/hmg/ddi363

TY - JOUR

T1 - Whole genome linkage scan of recurrent depressive disorder from the depression network study

AU - McGuffin, P.

AU - Knight, J.

AU - Breen, G.

AU - Brewster, S.

AU - Boyd, P. R.

AU - Craddock, N.

AU - Gill, M.

AU - Korszun, A.

AU - Maier, W.

AU - Middleton, L.

AU - Mors, O.

AU - Owen, M. J.

AU - Perry, J.

AU - Preisig, M.

AU - Reich, T.

AU - Rice, J.

AU - Rietschel, M.

AU - Jones, L.

AU - Sham, P.

AU - Farmer, A. E.

PY - 2005/11/15

Y1 - 2005/11/15

N2 - Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female-female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing). The region includes a gene, MTHFR, that in previous studies has been associated with depressive symptoms. Two other regions, on chromosomes 12q23.3-q24.11 and 13q31.1-q31.3, showed evidence for linkage with a nominal P <0.01. The 12q peak overlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and contains a gene, DAO, that has been associated with both bipolar disorder and schizophrenia. The 13q peak lies within a region previously linked strongly to panic disorder. A fourth modest peak with an LOD of greater than 1 on chromosome 15q lies within a region that showed genome-wide significant evidence of a recurrent depression locus in a previous sib-pair study. Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined.

AB - Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for female-female pairs exceeded 3 (but reduced to 2.73 when corrected for multiple testing). The region includes a gene, MTHFR, that in previous studies has been associated with depressive symptoms. Two other regions, on chromosomes 12q23.3-q24.11 and 13q31.1-q31.3, showed evidence for linkage with a nominal P <0.01. The 12q peak overlaps with a region previously implicated by linkage studies of unipolar and bipolar disorders and contains a gene, DAO, that has been associated with both bipolar disorder and schizophrenia. The 13q peak lies within a region previously linked strongly to panic disorder. A fourth modest peak with an LOD of greater than 1 on chromosome 15q lies within a region that showed genome-wide significant evidence of a recurrent depression locus in a previous sib-pair study. Both the 12q and the 15q findings remained significant at genome-wide level when the data from the present study and the previous reports were combined.

U2 - 10.1093/hmg/ddi363

DO - 10.1093/hmg/ddi363

M3 - Article

SN - 1460-2083

VL - 14

SP - 3337

EP - 3345

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 22

ER -

Whole genome linkage scan of recurrent depressive disorder from the depression network study

Abstract

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