TY - JOUR
T1 - Whole‐Body Magnetic Resonance Imaging Assessment of the Contributions of Adipose and Nonadipose Tissues to Cardiovascular Remodeling in Adolescents
AU - Hauser, Jakob
AU - Burden, Samuel
AU - Karunakaran, Ajanthiha
AU - Muthurangu, Vivek
AU - Taylor, Andrew
AU - Jones, Alexander
N1 - Funding Information:
Dr Jones is supported by a British Heart Foundation Intermediate Clinical Research Fellowship (FS/18/22/33479). Dr Hauser was funded as part of the Framework Package-7 project MD-Paedigree of the European Commission (grant to Dr Taylor; contract no. 600932). Dr Burden is currently funded as part of a British Heart Foundation Special Project held at King’s College London (SP/F/21/150013).
Publisher Copyright:
© 2023 The Authors.
PY - 2023/7/25
Y1 - 2023/7/25
N2 - BACKGROUND: Greater body mass index is associated with cardiovascular remodeling in adolescents. However, body mass index cannot differentiate between adipose and nonadipose tissues. We examined how visceral and subcutaneous adipose tissue are linked with markers of early cardiovascular remodeling, independently from nonadipose tissue. METHODS AND RESULTS: Whole-body magnetic resonance imaging was done in 82 adolescents (39 overweight/obese; 36 female; median age, 16.3 [interquartile range, 14.4–18.1] years) to measure body composition and cardiovascular remodeling markers. Left ventricular diastolic function was assessed by echocardiography. Waist, waist:height ratio, and body mass index z scores were calculated. Residualized nonadipose tissue, subcutaneous adipose tissue, and visceral adipose tissue variables, uncorrelated with each other, were constructed using partial regression modeling to allow comparison of their individual contributions in a 3-compartment body composition model. Cardiovascular variables mostly related to nonadipose rather than adipose tissue. Nonadipose tissue was correlated positively with left ventricular mass (r=0.81), end-diastolic volume (r=0.70), stroke volume (r=0.64), left ventricular mass:end-diastolic volume (r=0.37), and systolic blood pressure (r=0.35), and negatively with heart rate (r=−0.33) (all P<0.01). Subcutaneous adipose tissue was associated with worse left ventricular diastolic function (r=−0.42 to −0.48, P=0.0007– 0.02) and higher heart rates (r=0.34, P=0.007) but linked with better systemic vascular resistance (r=−0.35, P=0.006). There were no significant relationships with visceral adipose tissue and no associa-tions of any compartment with pulse wave velocity. CONCLUSIONS: Simple anthropometry does not reflect independent effects of nonadipose tissue and subcutaneous adipose tissue on the adolescent cardiovascular system. This could result in normal cardiovascular adaptations to growth being mis-interpreted as pathological sequelae of excess adiposity in studies reliant on such measures.
AB - BACKGROUND: Greater body mass index is associated with cardiovascular remodeling in adolescents. However, body mass index cannot differentiate between adipose and nonadipose tissues. We examined how visceral and subcutaneous adipose tissue are linked with markers of early cardiovascular remodeling, independently from nonadipose tissue. METHODS AND RESULTS: Whole-body magnetic resonance imaging was done in 82 adolescents (39 overweight/obese; 36 female; median age, 16.3 [interquartile range, 14.4–18.1] years) to measure body composition and cardiovascular remodeling markers. Left ventricular diastolic function was assessed by echocardiography. Waist, waist:height ratio, and body mass index z scores were calculated. Residualized nonadipose tissue, subcutaneous adipose tissue, and visceral adipose tissue variables, uncorrelated with each other, were constructed using partial regression modeling to allow comparison of their individual contributions in a 3-compartment body composition model. Cardiovascular variables mostly related to nonadipose rather than adipose tissue. Nonadipose tissue was correlated positively with left ventricular mass (r=0.81), end-diastolic volume (r=0.70), stroke volume (r=0.64), left ventricular mass:end-diastolic volume (r=0.37), and systolic blood pressure (r=0.35), and negatively with heart rate (r=−0.33) (all P<0.01). Subcutaneous adipose tissue was associated with worse left ventricular diastolic function (r=−0.42 to −0.48, P=0.0007– 0.02) and higher heart rates (r=0.34, P=0.007) but linked with better systemic vascular resistance (r=−0.35, P=0.006). There were no significant relationships with visceral adipose tissue and no associa-tions of any compartment with pulse wave velocity. CONCLUSIONS: Simple anthropometry does not reflect independent effects of nonadipose tissue and subcutaneous adipose tissue on the adolescent cardiovascular system. This could result in normal cardiovascular adaptations to growth being mis-interpreted as pathological sequelae of excess adiposity in studies reliant on such measures.
UR - http://www.scopus.com/inward/record.url?scp=85166772078&partnerID=8YFLogxK
U2 - 10.1161/JAHA.123.030221
DO - 10.1161/JAHA.123.030221
M3 - Article
SN - 2047-9980
VL - 12
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 15
M1 - e030221
ER -
