TY - JOUR
T1 - Will Oral Food Challenges Still Be Part of Allergy Care in 10 Years’ Time?
AU - Patel, Nandinee
AU - Shreffler, Wayne G.
AU - Custovic, Adnan
AU - Santos, Alexandra F.
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/4
Y1 - 2023/4
N2 - Oral food challenges (OFCs) are currently the definitive diagnostic procedure in food allergy. Their design has evolved over the decades to maximize safety, optimize convenience, and address several specific clinical questions. However, they are a resource-intensive investigation that carry a risk for severe allergic reaction in which fatal outcomes, although rare, have been reported. In this review, we explore the many roles that OFC fulfil in the clinical and research settings. We also discuss progress that has been made in developing alternative diagnostic tools and how far these have reached in offering a viable replacement to OFC in clinical practice. Finally, we discuss the ongoing importance of research OFC to improve the future diagnostic capabilities of novel diagnostic tools.
AB - Oral food challenges (OFCs) are currently the definitive diagnostic procedure in food allergy. Their design has evolved over the decades to maximize safety, optimize convenience, and address several specific clinical questions. However, they are a resource-intensive investigation that carry a risk for severe allergic reaction in which fatal outcomes, although rare, have been reported. In this review, we explore the many roles that OFC fulfil in the clinical and research settings. We also discuss progress that has been made in developing alternative diagnostic tools and how far these have reached in offering a viable replacement to OFC in clinical practice. Finally, we discuss the ongoing importance of research OFC to improve the future diagnostic capabilities of novel diagnostic tools.
KW - Anaphylaxis
KW - Basophil activation test
KW - Double-blind placebo-controlled food challenge
KW - Food allergy
KW - IgE
KW - Oral food challenge
UR - http://www.scopus.com/inward/record.url?scp=85150025427&partnerID=8YFLogxK
U2 - 10.1016/j.jaip.2023.02.010
DO - 10.1016/j.jaip.2023.02.010
M3 - Review article
C2 - 36822320
AN - SCOPUS:85150025427
SN - 2213-2198
VL - 11
SP - 988
EP - 996
JO - Journal of Allergy and Clinical Immunology: In Practice
JF - Journal of Allergy and Clinical Immunology: In Practice
IS - 4
ER -