Will Oral Food Challenges Still Be Part of Allergy Care in 10 Years’ Time?

Nandinee Patel, Wayne G. Shreffler, Adnan Custovic, Alexandra F. Santos*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Oral food challenges (OFCs) are currently the definitive diagnostic procedure in food allergy. Their design has evolved over the decades to maximize safety, optimize convenience, and address several specific clinical questions. However, they are a resource-intensive investigation that carry a risk for severe allergic reaction in which fatal outcomes, although rare, have been reported. In this review, we explore the many roles that OFC fulfil in the clinical and research settings. We also discuss progress that has been made in developing alternative diagnostic tools and how far these have reached in offering a viable replacement to OFC in clinical practice. Finally, we discuss the ongoing importance of research OFC to improve the future diagnostic capabilities of novel diagnostic tools.

Original languageEnglish
Pages (from-to)988-996
Number of pages9
JournalJournal of Allergy and Clinical Immunology: In Practice
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 2023

Keywords

  • Anaphylaxis
  • Basophil activation test
  • Double-blind placebo-controlled food challenge
  • Food allergy
  • IgE
  • Oral food challenge

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