Wnt6 marks sites of epithelial transformations in the chick embryo

F R Schubert, R C Mootoosamy, E H Walters, A Graham, L Tumiotto, A E Munsterberg, A Lumsden, S Dietrich

Research output: Contribution to journalArticlepeer-review

81 Citations (Scopus)

Abstract

In a screen for Wnt genes executing the patterning function of the vertebrate surface ectoderm, we have isolated a novel chick Wnt gene, chick Wnt6. This gene encodes the first pan-epidermal Writ signalling molecule. Further sites of expression are the boundary of the early neural plate and surface ectoderm, the roof of mesencephalon, pretectum and dorsal thalamus, the differentiating heart, and the otic vesicle. The precise sites of Wnt6 expression coincide with crucial changes in tissue architecture, namely epithelial remodelling and epithelial-mesenchymal transformation (EMT). Moreover, the expression of Wnt6 is closely associated with areas of Bmp signalling. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)143 - 148
Number of pages6
JournalMechanisms of Development
Volume114
Issue number1-2
DOIs
Publication statusPublished - 2002

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