World Workshop on Oral Medicine VI: a systematic review of the treatment of mucous membrane pemphigoid

J Taylor; R McMillan; M Shephard; J Setterfield; R Ahmed; M Carrozzo; S Grando; M Mignogna; M Kuten-Shorrer; T Musbah; A Elia; R McGowan; A R Kerr; M S Greenberg; T Hodgson; D Sirois

doi:10.1016/j.oooo.2015.01.024

World Workshop on Oral Medicine VI: a systematic review of the treatment of mucous membrane pemphigoid

J Taylor, R McMillan, M Shephard, J Setterfield, R Ahmed, M Carrozzo, S Grando, M Mignogna, M Kuten-Shorrer, T Musbah, A Elia, R McGowan, A R Kerr, M S Greenberg, T Hodgson, D Sirois

Centre for Host Microbiome Interactions

Research output: Contribution to journal › Article › peer-review

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Abstract

OBJECTIVE: To determine the efficacy and safety of interventions for mucous membrane pemphigoid (MMP).

STUDY DESIGN: We conducted a systematic review from 2003 to 2013 according to the Cochrane Collaboration methodology. Randomized controlled trials (RCTs) or controlled clinical trials and observational studies were included, with diagnosis confirmed by clinical, histopathologic, and immunofluorescence criteria. The primary outcome was lesion remission or healing; several relevant secondary outcomes were also included.

RESULTS: In the final analysis, 1 RCT and 32 observational studies were included. The one included RCT with a high risk of bias in multiple domains found limited evidence that pentoxifylline, combined with corticosteroid and cyclophosphamide, was more effective than standard therapy (corticosteroid + cyclophosphamide alone) for ocular MMP. We summarize here the outcomes from 32 observational studies examining 242 patients across 19 unique treatments. Interventions that show promise include rituximab and intravenous immunoglobulin.

CONCLUSIONS: This systematic review is the most recent since 2003-2009. There is still lack of high-quality research providing evidence-based MMP treatments.

Original language	English
Pages (from-to)	161-71.e20
Journal	Oral surgery, oral medicine, oral pathology and oral radiology
Volume	120
Issue number	2
DOIs	https://doi.org/10.1016/j.oooo.2015.01.024
Publication status	Published - Aug 2015

Keywords

Anti-Infective Agents
Cyclophosphamide
Dapsone
Glucocorticoids
Humans
Immunoglobulins, Intravenous
Immunosuppressive Agents
Pemphigoid, Benign Mucous Membrane
Quality of Life
Randomized Controlled Trials as Topic

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10.1016/j.oooo.2015.01.024

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Taylor, J., McMillan, R., Shephard, M., Setterfield, J., Ahmed, R., Carrozzo, M., Grando, S., Mignogna, M., Kuten-Shorrer, M., Musbah, T., Elia, A., McGowan, R., Kerr, A. R., Greenberg, M. S., Hodgson, T., & Sirois, D. (2015). World Workshop on Oral Medicine VI: a systematic review of the treatment of mucous membrane pemphigoid. Oral surgery, oral medicine, oral pathology and oral radiology, 120(2), 161-71.e20. https://doi.org/10.1016/j.oooo.2015.01.024

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title = "World Workshop on Oral Medicine VI: a systematic review of the treatment of mucous membrane pemphigoid",

abstract = "OBJECTIVE: To determine the efficacy and safety of interventions for mucous membrane pemphigoid (MMP).STUDY DESIGN: We conducted a systematic review from 2003 to 2013 according to the Cochrane Collaboration methodology. Randomized controlled trials (RCTs) or controlled clinical trials and observational studies were included, with diagnosis confirmed by clinical, histopathologic, and immunofluorescence criteria. The primary outcome was lesion remission or healing; several relevant secondary outcomes were also included.RESULTS: In the final analysis, 1 RCT and 32 observational studies were included. The one included RCT with a high risk of bias in multiple domains found limited evidence that pentoxifylline, combined with corticosteroid and cyclophosphamide, was more effective than standard therapy (corticosteroid + cyclophosphamide alone) for ocular MMP. We summarize here the outcomes from 32 observational studies examining 242 patients across 19 unique treatments. Interventions that show promise include rituximab and intravenous immunoglobulin.CONCLUSIONS: This systematic review is the most recent since 2003-2009. There is still lack of high-quality research providing evidence-based MMP treatments.",

keywords = "Anti-Infective Agents, Cyclophosphamide, Dapsone, Glucocorticoids, Humans, Immunoglobulins, Intravenous, Immunosuppressive Agents, Pemphigoid, Benign Mucous Membrane, Quality of Life, Randomized Controlled Trials as Topic",

author = "J Taylor and R McMillan and M Shephard and J Setterfield and R Ahmed and M Carrozzo and S Grando and M Mignogna and M Kuten-Shorrer and T Musbah and A Elia and R McGowan and Kerr, {A R} and Greenberg, {M S} and T Hodgson and D Sirois",

year = "2015",

month = aug,

doi = "10.1016/j.oooo.2015.01.024",

language = "English",

volume = "120",

pages = "161--71.e20",

journal = "Oral surgery, oral medicine, oral pathology and oral radiology",

issn = "2212-4411",

publisher = "Elsevier",

number = "2",

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Taylor, J, McMillan, R, Shephard, M, Setterfield, J, Ahmed, R, Carrozzo, M, Grando, S, Mignogna, M, Kuten-Shorrer, M, Musbah, T, Elia, A, McGowan, R, Kerr, AR, Greenberg, MS, Hodgson, T & Sirois, D 2015, 'World Workshop on Oral Medicine VI: a systematic review of the treatment of mucous membrane pemphigoid', Oral surgery, oral medicine, oral pathology and oral radiology, vol. 120, no. 2, pp. 161-71.e20. https://doi.org/10.1016/j.oooo.2015.01.024

TY - JOUR

T1 - World Workshop on Oral Medicine VI

T2 - a systematic review of the treatment of mucous membrane pemphigoid

AU - Taylor, J

AU - McMillan, R

AU - Shephard, M

AU - Setterfield, J

AU - Ahmed, R

AU - Carrozzo, M

AU - Grando, S

AU - Mignogna, M

AU - Kuten-Shorrer, M

AU - Musbah, T

AU - Elia, A

AU - McGowan, R

AU - Kerr, A R

AU - Greenberg, M S

AU - Hodgson, T

AU - Sirois, D

PY - 2015/8

Y1 - 2015/8

N2 - OBJECTIVE: To determine the efficacy and safety of interventions for mucous membrane pemphigoid (MMP).STUDY DESIGN: We conducted a systematic review from 2003 to 2013 according to the Cochrane Collaboration methodology. Randomized controlled trials (RCTs) or controlled clinical trials and observational studies were included, with diagnosis confirmed by clinical, histopathologic, and immunofluorescence criteria. The primary outcome was lesion remission or healing; several relevant secondary outcomes were also included.RESULTS: In the final analysis, 1 RCT and 32 observational studies were included. The one included RCT with a high risk of bias in multiple domains found limited evidence that pentoxifylline, combined with corticosteroid and cyclophosphamide, was more effective than standard therapy (corticosteroid + cyclophosphamide alone) for ocular MMP. We summarize here the outcomes from 32 observational studies examining 242 patients across 19 unique treatments. Interventions that show promise include rituximab and intravenous immunoglobulin.CONCLUSIONS: This systematic review is the most recent since 2003-2009. There is still lack of high-quality research providing evidence-based MMP treatments.

AB - OBJECTIVE: To determine the efficacy and safety of interventions for mucous membrane pemphigoid (MMP).STUDY DESIGN: We conducted a systematic review from 2003 to 2013 according to the Cochrane Collaboration methodology. Randomized controlled trials (RCTs) or controlled clinical trials and observational studies were included, with diagnosis confirmed by clinical, histopathologic, and immunofluorescence criteria. The primary outcome was lesion remission or healing; several relevant secondary outcomes were also included.RESULTS: In the final analysis, 1 RCT and 32 observational studies were included. The one included RCT with a high risk of bias in multiple domains found limited evidence that pentoxifylline, combined with corticosteroid and cyclophosphamide, was more effective than standard therapy (corticosteroid + cyclophosphamide alone) for ocular MMP. We summarize here the outcomes from 32 observational studies examining 242 patients across 19 unique treatments. Interventions that show promise include rituximab and intravenous immunoglobulin.CONCLUSIONS: This systematic review is the most recent since 2003-2009. There is still lack of high-quality research providing evidence-based MMP treatments.

KW - Anti-Infective Agents

KW - Cyclophosphamide

KW - Dapsone

KW - Glucocorticoids

KW - Humans

KW - Immunoglobulins, Intravenous

KW - Immunosuppressive Agents

KW - Pemphigoid, Benign Mucous Membrane

KW - Quality of Life

KW - Randomized Controlled Trials as Topic

U2 - 10.1016/j.oooo.2015.01.024

DO - 10.1016/j.oooo.2015.01.024

M3 - Article

C2 - 25953640

SN - 2212-4411

VL - 120

SP - 161-71.e20

JO - Oral surgery, oral medicine, oral pathology and oral radiology

JF - Oral surgery, oral medicine, oral pathology and oral radiology

IS - 2

ER -

World Workshop on Oral Medicine VI: a systematic review of the treatment of mucous membrane pemphigoid

Abstract

Keywords

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