Zebrafish brain mapping-standardized spaces, length scales, and the power of N and n

Paul R. Hunter, Aenea C. Hendry, Andrew S. Lowe*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Mapping anatomical and functional parameters of the zebrafish brain is moving apace. Research communities undertaking such studies are becoming ever larger and more diverse. The unique features, tools, and technologies associated with zebrafish are propelling them as the 21st century model organism for brain mapping. Uniquely positioned as a vertebrate model system, the zebrafish enables imaging of anatomy and function at different length scales from intraneuronal compartments to sparsely distributed whole brain patterns. With a variety of diverse and established statistical modeling and analytic methods available from the wider brain mapping communities, the richness of zebrafish neuroimaging data is being realized. The statistical power of population observations (N) within and across many samples (n) projected onto a standardized space will provide vast databases for data-driven biological approaches. This article reviews key brain mapping initiatives at different levels of scale that highlight the potential of zebrafish brain mapping. By way of introduction to the next wave of brain mappers, an accessible introduction to the key concepts and caveats associated with neuroimaging are outlined and discussed.

Original languageEnglish
Pages (from-to)557-568
Number of pages12
JournalDevelopmental Neurobiology
Issue number6
Publication statusPublished - 1 Jun 2015


  • Brain mapping
  • Function
  • Neuroimaging
  • Standardized space
  • Zebrafish


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