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Zinc and cadmium in the aetiology and pathogenesis of osteoarthritis and rheumatoid arthritis

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Zinc and cadmium in the aetiology and pathogenesis of osteoarthritis and rheumatoid arthritis. / Frangos, Theoharris; Maret, Wolfgang.

In: Nutrients, Vol. 13, No. 1, 53, 01.2021, p. 1-22.

Research output: Contribution to journalReview articlepeer-review

Harvard

Frangos, T & Maret, W 2021, 'Zinc and cadmium in the aetiology and pathogenesis of osteoarthritis and rheumatoid arthritis', Nutrients, vol. 13, no. 1, 53, pp. 1-22. https://doi.org/10.3390/nu13010053

APA

Frangos, T., & Maret, W. (2021). Zinc and cadmium in the aetiology and pathogenesis of osteoarthritis and rheumatoid arthritis. Nutrients, 13(1), 1-22. [53]. https://doi.org/10.3390/nu13010053

Vancouver

Frangos T, Maret W. Zinc and cadmium in the aetiology and pathogenesis of osteoarthritis and rheumatoid arthritis. Nutrients. 2021 Jan;13(1):1-22. 53. https://doi.org/10.3390/nu13010053

Author

Frangos, Theoharris ; Maret, Wolfgang. / Zinc and cadmium in the aetiology and pathogenesis of osteoarthritis and rheumatoid arthritis. In: Nutrients. 2021 ; Vol. 13, No. 1. pp. 1-22.

Bibtex Download

@article{4a6a2952f28b4b199c1bf2fdc688aef6,
title = "Zinc and cadmium in the aetiology and pathogenesis of osteoarthritis and rheumatoid arthritis",
abstract = "Osteoarthritis (OA) and rheumatoid arthritis (RA) are inflammatory articular conditions with different aetiology, but both result in joint damage. The nutritionally essential metal zinc (Zn2+) and the non-essential metal cadmium (Cd2+) have roles in these arthritic diseases as effectors of the immune system, inflammation, and metabolism. Despite both metal ions being redox-inert in biology, they affect the redox balance. It has been known for decades that zinc decreases in the blood of RA patients. It is largely unknown, however, whether this change is only a manifestation of an acute phase response in inflammation or relates to altered availability of zinc in tissues and consequently requires changes of zinc in the diet. As a cofactor in over 3000 human proteins and as a signaling ion, zinc affects many pathways relevant for arthritic disease. How it affects the diseases is not just a question of zinc status, but also an issue of mutations in the many proteins that maintain cellular zinc homoeostasis, such as zinc transporters of the ZIP (Zrt-/Irt-like protein) and ZnT families and metallothioneins, and the multiple pathways that change the expression of these proteins. Cadmium interferes with zinc{\textquoteright}s functions and there is increased uptake under zinc deficiency. Remarkably, cadmium exposure through inhalation is now recognized in the activation of macrophages to a pro-inflammatory state and suggested as a trigger of a specific form of nodular RA. Here, we discuss how these metal ions participate in the genetic, metabolic, and environmental factors that lead to joint destruction. We conclude that both metal ions should be monitored routinely in arthritic disease and that there is untapped potential for prognosis and treatment.",
keywords = "Cadmium, Osteoarthritis, Rheumatoid arthritis, Zinc",
author = "Theoharris Frangos and Wolfgang Maret",
note = "Funding Information: The support of Zinpro Corporation, Eden Prairie, MN for our experimental work is gratefully acknowledged. We thank Hajo Haase (TU Berlin, Germany) for critical reading of the manuscript. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = jan,
doi = "10.3390/nu13010053",
language = "English",
volume = "13",
pages = "1--22",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Zinc and cadmium in the aetiology and pathogenesis of osteoarthritis and rheumatoid arthritis

AU - Frangos, Theoharris

AU - Maret, Wolfgang

N1 - Funding Information: The support of Zinpro Corporation, Eden Prairie, MN for our experimental work is gratefully acknowledged. We thank Hajo Haase (TU Berlin, Germany) for critical reading of the manuscript. Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/1

Y1 - 2021/1

N2 - Osteoarthritis (OA) and rheumatoid arthritis (RA) are inflammatory articular conditions with different aetiology, but both result in joint damage. The nutritionally essential metal zinc (Zn2+) and the non-essential metal cadmium (Cd2+) have roles in these arthritic diseases as effectors of the immune system, inflammation, and metabolism. Despite both metal ions being redox-inert in biology, they affect the redox balance. It has been known for decades that zinc decreases in the blood of RA patients. It is largely unknown, however, whether this change is only a manifestation of an acute phase response in inflammation or relates to altered availability of zinc in tissues and consequently requires changes of zinc in the diet. As a cofactor in over 3000 human proteins and as a signaling ion, zinc affects many pathways relevant for arthritic disease. How it affects the diseases is not just a question of zinc status, but also an issue of mutations in the many proteins that maintain cellular zinc homoeostasis, such as zinc transporters of the ZIP (Zrt-/Irt-like protein) and ZnT families and metallothioneins, and the multiple pathways that change the expression of these proteins. Cadmium interferes with zinc’s functions and there is increased uptake under zinc deficiency. Remarkably, cadmium exposure through inhalation is now recognized in the activation of macrophages to a pro-inflammatory state and suggested as a trigger of a specific form of nodular RA. Here, we discuss how these metal ions participate in the genetic, metabolic, and environmental factors that lead to joint destruction. We conclude that both metal ions should be monitored routinely in arthritic disease and that there is untapped potential for prognosis and treatment.

AB - Osteoarthritis (OA) and rheumatoid arthritis (RA) are inflammatory articular conditions with different aetiology, but both result in joint damage. The nutritionally essential metal zinc (Zn2+) and the non-essential metal cadmium (Cd2+) have roles in these arthritic diseases as effectors of the immune system, inflammation, and metabolism. Despite both metal ions being redox-inert in biology, they affect the redox balance. It has been known for decades that zinc decreases in the blood of RA patients. It is largely unknown, however, whether this change is only a manifestation of an acute phase response in inflammation or relates to altered availability of zinc in tissues and consequently requires changes of zinc in the diet. As a cofactor in over 3000 human proteins and as a signaling ion, zinc affects many pathways relevant for arthritic disease. How it affects the diseases is not just a question of zinc status, but also an issue of mutations in the many proteins that maintain cellular zinc homoeostasis, such as zinc transporters of the ZIP (Zrt-/Irt-like protein) and ZnT families and metallothioneins, and the multiple pathways that change the expression of these proteins. Cadmium interferes with zinc’s functions and there is increased uptake under zinc deficiency. Remarkably, cadmium exposure through inhalation is now recognized in the activation of macrophages to a pro-inflammatory state and suggested as a trigger of a specific form of nodular RA. Here, we discuss how these metal ions participate in the genetic, metabolic, and environmental factors that lead to joint destruction. We conclude that both metal ions should be monitored routinely in arthritic disease and that there is untapped potential for prognosis and treatment.

KW - Cadmium

KW - Osteoarthritis

KW - Rheumatoid arthritis

KW - Zinc

UR - http://www.scopus.com/inward/record.url?scp=85098633516&partnerID=8YFLogxK

U2 - 10.3390/nu13010053

DO - 10.3390/nu13010053

M3 - Review article

AN - SCOPUS:85098633516

VL - 13

SP - 1

EP - 22

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 1

M1 - 53

ER -

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