Zinc in cellular regulation: The nature and significance of “zinc signals”

Wolfgang Maret*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

232 Citations (Scopus)
205 Downloads (Pure)


In the last decade, we witnessed discoveries that established Zn2+ as a second major signalling metal ion in the transmission of information within cells and in communication between cells. Together with Ca2+ and Mg2+, Zn2+ covers biological regulation with redox-inert metal ions over many orders of magnitude in concentrations. The regulatory functions of zinc ions, together with their functions as a cofactor in about three thousand zinc metalloproteins, impact virtually all aspects of cell biology. This article attempts to define the regulatory functions of zinc ions, and focuses on the nature of zinc signals and zinc signalling in pathways where zinc ions are either extracellular stimuli or intracellular messengers. These pathways interact with Ca2+, redox, and phosphorylation signalling. The regulatory functions of zinc require a complex system of precise homeostatic control for transients, subcellular distribution and traffic, organellar homeostasis, and vesicular storage and exocytosis of zinc ions.

Original languageEnglish
Article number2285
Number of pages12
JournalInternational Journal of Molecular Sciences
Issue number11
Early online date31 Oct 2017
Publication statusE-pub ahead of print - 31 Oct 2017


  • Homeostasis
  • Regulation
  • Signalling
  • Zinc


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