A NEW QUANTITATIVE METHOD FOR THE DETERMINATION OF REGIONAL RATES OF CEREBRAL PROTEIN SYNTHESIS FROM L-[1 −11C]LEUCINE PET IMAGES

    Student thesis: Master's ThesisMaster of Science

    Abstract

    The work that we are presenting comes from a collaboration between the Bioengineering group of the University of Padova and the Section of Neuroadaptation and Protein Metabolism (SNPM).
    SNPM is an integral part of the Neuroscience Research community at the National Institutes of Health (NIH), the primary United States Federal agency for conducting and supporting medical research. SNPM laboratories are located on the NIH campus in Bethesda, Maryland in the Division of Intramural Research of the National Institute of Mental Health (NIMH).
    The aim of SNPM research is to understand the role of protein metabolism in adaptive responses of the nervous system and to do it they develop, apply, and refine imaging methods that can be used to quantitatively measure these changes in vivo in all structures of the nervous system in animals and in man.
    The role of the Bioengineering group of Padova University in this collaboration is to provide ideas to develop and improve these new quantification methods, using its experience in kinetic model design.
    Date of Award2009
    Original languageEnglish
    Awarding Institution
    • King's College London
    • University of Padua
    SupervisorAlessandra Bertoldo (Supervisor) & Kathleen Schmidt (Supervisor)

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