Modifying pentamidine blood-brain barrier transport through ion-pair formation

Student thesis: Doctoral ThesisDoctor of Philosophy

Abstract

Human African trypanosomiasis (HAT) is fatal unless treated. Pentamidine has been used to treat first-stage (hemolymphatic) HAT since the 1940s, but it is ineffective against second-stage (meningoencephalitic, or central nervous system) infection. Research has suggested that hOCT1 and P-gp are involved in the transport of pentamidine across the blood-brain barrier (BBB). The aim of this study was to investigate if through the formation of ion-pairs the passive diffusion and hOCT1 and P-gp mediated BBB transport of pentamidine could be improved.
Date of Award1 Sept 2020
Original languageEnglish
Awarding Institution
  • King's College London
SupervisorSarah Thomas (Supervisor) & Stuart Jones (Supervisor)

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