Novel nuclear imaging approaches for the detection of heart failure

Student thesis: Doctoral ThesisDoctor of Philosophy

Abstract

Medical imaging plays a critical and increasingly prominent role in both the diagnosis and characterisation of cardiac pathologies. Whilst the measurement of regional changes in cardiac dimensions or contractility using echocardiography and magnetic resonance imaging are powerful techniques for the diagnosis of advanced cardiovascular disease or acute cardiovascular injury, they are limited in being able to detect evolving dysfunction or tissue injury in chronic cardiovascular syndromes in its early stages, where intervention would be most beneficial. The aim of the work carried out in this thesis was to develop and demonstrate the potential of nuclear molecular imaging probes targeted at the pathological biochemical processes which precede this contractile dysfunction. Such probes could provide opportunities for the early detection of evolving heart failure, better understanding of the progression of chronic cardiovascular diseases themselves, and potentially accelerate the development of cardioprotective drugs by providing an earlier readout of drug effectiveness. This thesis is divided into three main experimental sections; initial identification and evaluation of promising radiotracers using the Langendorff isolated heart model, the development of robust and physiologically relevant in vivo models of cardiac hypoxia, the development of an in vivo model of chronic anthracycline induced cardiotoxicity. Our molecular imaging agents were progressively evaluated through each stage of this screening and evaluation processes.
Date of Award1 May 2020
Original languageEnglish
Awarding Institution
  • King's College London
SupervisorRichard Southworth (Supervisor) & James Clark (Supervisor)

Cite this

'