Neonatal naive CD4+ T cells have distinct functionality to adult naive CD4+ T cells, most strikingly by their inherent capacity to express CXCL8. This thesis sets out to investigate the control of neonatal T cell functionality by: developing a novel CXCL8-secretion cell assay to facilitate their better characterisation
in vitro; exploring the neonatal naive CD4+ T cell epigenetic landscapes; and determining the immunology, including T cell functionality, of neonates born to SARS-CoV-2 exposed mothers. This thesis provides new evidence that neonatal naive CD4+ T cells and their functionality are influenced by both epigenetics, and environmental stimuli.
| Date of Award | 1 Sept 2022 |
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| Original language | English |
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| Awarding Institution | |
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| Supervisor | Deena Gibbons (Supervisor) & Paul Lavender (Supervisor) |
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The control of T cell functionality in the human neonate
Gee, S. (Author). 1 Sept 2022
Student thesis: Doctoral Thesis › Doctor of Philosophy