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Federico Formenti

Dr Federico Formenti

Senior Lecturer in Human Physiology

Start date at Kings: 4/01/2015

Contact details:

Postal address:
Shepherds House
Guy's
London
United Kingdom

Department

Research interests

Arterial oxygen sensing

We measure arterial partial pressure of oxygen as an index of overall ventilation and perfusion in the mechanically ventilated lung. This continuous oxygen monitoring affords the real time study of dynamic cardiopulmonary physiology, providing detailed information on pulmonary gas exchange.

Collaborators: Andrew Farmery and Clive Hahn (Oxford), Anders Larsson and Goran Hedenstierna (Uppsala), Luigi Camporota (KCL)

 

Human responses to hypoxia

With the generous help of patients, we explored how a protein called hypoxia-inducible factor is involved in the regulation of human responses to hypoxia. We observed that mutations affecting the hypoxia-inducible factor pathway can have an impact on human respiration and metabolism at whole body level, with implications for high altitude training.

Collaborators: Keith Dorrington and Peter Robbins (Oxford), Fulvio Della Ragione and Silverio Perrotta (Naples), Andrew Murray (Cambridge)

 

Exercise physiology and biomechanics

We studied the energetics and biomechanics of ice skating and cross country skiing with a historical perspective; we showed how fast and how far people could travel on ice skates and cross country skis since these were first made, and how performance improved with technological and technical development. We also investigated the effect of different pedalling rates on the oxygen uptake of cycling exercise, showing that the work required to spin the lower limbs can be a substantial determinant of overall oxygen uptake.

Collaborators: Alberto Minetti (Milan), Fabio Borrani (Lausanne), Koji Ishida (Nagoya), Nicholas Stergiou (Omaha, NE)

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