Dr Mark McPhail
Snr Clinical Lecturer in Experimental Medicine
Start date at Kings: 3/04/2017
Contact details:
Postal address:
tbc
James Black Centre
Denmark Hill
James Black Centre
Denmark Hill
United Kingdom
E-mail: mark.mcphail@kcl.ac.uk
Department
Research interests
Mark McPhail is a Senior Lecturer and Consultant in Liver Critical Care and Hepatology in the Institute of Liver Studies, King's College London and Department of Hepatology at Imperial College. His main research interests are in outcome prediction, metabolism and immunity in liver failure syndromes. He is also working on novel methods to diagnose and monitor hepatic encephalopathy and sepsis.
He also holds a PhD in Molecular Physics from the University of Strathclyde. During his doctorate he collaborated with the NASA Jet Propulsion Laboratory, Pasadena and the University of Bologna on modelling rotation and vibration of atmospheric molecules involved in ozone depletion and global warming.
While retraining in medicine following his PhD he maintained an interest in teaching physics as an Associate Lecturer with the Open University. He continues to develop an interest in statistics and has published widely using multivariate methods.
His present focus is on using metabolic profiling to improve prognostication and find novel pathways for metabolic modulation of innate immune responses through the action of lipids on CD14+ monocytes in patients with acute and acute-on-chronic liver failure.
L-Ornithine L-Aspartate (LOLA) for Hepatic Encephalopathy in Cirrhosis: Results of Randomized Controlled Trials and Meta-Analyses
Butterworth, R. F. & McPhail, M. J. W., 31 Jan 2019, In : Drugs.Research output: Contribution to journal › Review article
Update on the management of acute liver failure
Trovato, F. M., Rabinowich, L. & McPhail, M. J. W., 28 Jan 2019, In : CURRENT OPINION IN CRITICAL CARE.Research output: Contribution to journal › Article
The Role of Monocytes and Macrophages in Acute and Acute-on-Chronic Liver Failure
Triantafyllou, E., Woollard, K. J., McPhail, M. J. W., Antoniades, C. G. & Possamai, L. A., 14 Dec 2018, In : Frontiers in Immunology. 9Research output: Contribution to journal › Review article
Improvement in Hepatic Encephalopathy with Rifaximin Is Associated with Distinct Changes in the Metagenomic Species in the Saliva and Stool Microbiome and a Reduction in Systemic Inflammation - Results of the Rifsys Randomized Controlled Trial.
Patel, V. C., McPhail, M. J., Zamalloa, A., Stoy, S., Vijay, G. K. M., Witherden, E., Lee, S., Shoaie, S., Huang, X., Rogers, G., Choo, J., Zia, R., Edwards, L., Gray, E., Woodhouse, C. A., Gencer, S., Cohen, M., Wendon, J., Erhlich, S. D., Bruce, K. & 1 others, Dec 2018, In : Hepatology. 68, 6, p. 1462A-1463AResearch output: Contribution to journal › Meeting Abstract
Top downloads
- 158
Multivariate metabotyping of plasma accurately predicts survival in patients with decompensated cirrhosis.
Research output: Contribution to journal › Article
downloads - 33
Update on the management of acute liver failure
Research output: Contribution to journal › Article
downloads - 19
Metabolic phenotype of skeletal muscle in early critical illness
Research output: Contribution to journal › Article
downloads - 12
High-Speed Quantitative UPLC-MS Analysis of Multiple Amines in Human Plasma and Serum via Precolumn Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate: Application to Acetaminophen-Induced Liver Failure
Research output: Contribution to journal › Article
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