Dr Mark McPhail

Snr Clinical Lecturer in Experimental Medicine

Start date at Kings: 3/04/2017

Contact details:

Department

Inflammation Biology

Research interests

Mark McPhail is a Senior Lecturer and Consultant in Liver Critical Care and Hepatology in the Institute of Liver Studies, King's College London and Department of Hepatology at Imperial College. His main research interests are in outcome prediction, metabolism and immunity in liver failure syndromes. He is also working on novel methods to diagnose and monitor hepatic encephalopathy and sepsis.

He also holds a PhD in Molecular Physics from the University of Strathclyde. During his doctorate he collaborated with the NASA Jet Propulsion Laboratory, Pasadena and the University of Bologna on modelling rotation and vibration of atmospheric molecules involved in ozone depletion and global warming.

While retraining in medicine following his PhD he maintained an interest in teaching physics as an Associate Lecturer with the Open University. He continues to develop an interest in statistics and has published widely using multivariate methods.

His present focus is on using metabolic profiling to improve prognostication and find novel pathways for metabolic modulation of innate immune responses through the action of lipids on CD14+ monocytes in patients with acute and acute-on-chronic liver failure.

Latest Research Outputs

2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia
Fitzpatrick, S. F., Lambden, S., Macias, D., Puthucheary, Z., Pietsch, S., Mendil, L., McPhail, M. J. W. & Johnson, R. S., 3 Mar 2020, In : Frontiers in Physiology. 11, 147.
Research output: Contribution to journal › Article
A 'real-world' analysis of risk factors for post liver transplant delirium and the effect on length of stay
Tavabie, O. D., Colwill, M., Adamson, R., McPhail, M. J. W., Bernal, W., Jassem, W., Prachialias, A., Heneghan, M., Aluvihare, V. R. & Agarwal, K., 9 Jan 2020, In : European Journal of Gastroenterology and Hepatology.
Research output: Contribution to journal › Article
Significant lung injury and its prognostic significance in acute liver failure: a cohort analysis
Dong, V., Sun, K., Gottfried, M., Cardoso, F. S., McPhail, M. J., Todd Stravitz, R., Lee, W. M. & Karvellas, C. J., 30 Sep 2019, In : LIVER INTERNATIONAL.
Research output: Contribution to journal › Article
Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland
DDD Study, 1 Sep 2019, In : QJM. 112, 9, p. 724-729 6 p.
Research output: Contribution to journal › Article

View all (100) »

Top downloads

Multivariate metabotyping of plasma accurately predicts survival in patients with decompensated cirrhosis.
Research output: Contribution to journal › Article
214
downloads
Metabolic phenotype of skeletal muscle in early critical illness
Research output: Contribution to journal › Article
141
downloads
Update on the management of acute liver failure
Research output: Contribution to journal › Article
129
downloads
Improving the Diagnostic Criteria for Primary Liver Graft Nonfunction in Adults Utilizing Standard and Transportable Laboratory Parameters: An Outcome-Based Analysis
Research output: Contribution to journal › Article
91
downloads
High-Speed Quantitative UPLC-MS Analysis of Multiple Amines in Human Plasma and Serum via Precolumn Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate: Application to Acetaminophen-Induced Liver Failure
Research output: Contribution to journal › Article
89
downloads

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