Dr Mark McPhail

Snr Clinical Lecturer in Experimental Medicine

Start date at Kings: 3/04/2017

Contact details:

Postal address:

tbc
James Black Centre
Denmark Hill

United Kingdom

E-mail: mark.mcphail@kcl.ac.uk

Department

Inflammation Biology

Research interests

Mark McPhail is a Senior Lecturer and Consultant in Liver Critical Care and Hepatology in the Institute of Liver Studies, King's College London and Department of Hepatology at Imperial College. His main research interests are in outcome prediction, metabolism and immunity in liver failure syndromes. He is also working on novel methods to diagnose and monitor hepatic encephalopathy and sepsis.

He also holds a PhD in Molecular Physics from the University of Strathclyde. During his doctorate he collaborated with the NASA Jet Propulsion Laboratory, Pasadena and the University of Bologna on modelling rotation and vibration of atmospheric molecules involved in ozone depletion and global warming.

While retraining in medicine following his PhD he maintained an interest in teaching physics as an Associate Lecturer with the Open University. He continues to develop an interest in statistics and has published widely using multivariate methods.

His present focus is on using metabolic profiling to improve prognostication and find novel pathways for metabolic modulation of innate immune responses through the action of lipids on CD14+ monocytes in patients with acute and acute-on-chronic liver failure.

Latest Research Outputs

Immunometabolic profiling of ascites from patients with acute-on-chronic liver failure reveals increased MerTK plus immunosuppressive myeloid cells and cell death markers with preferential lipid metabolism compared to cirrhosis without organ failure
Singanayagam, A., Erminelli, D., Triantafyllou, E., Bernsmeier, C., Tunc, E., Krasniqi, M., Patel, V., Lebosse, F., Nathwani, R., Atkinson, A., Dhar, A., Heneghan, M., Auzinger, G., Khamri, W., Adams, D., Wendon, J., Thursz, M., McPhail, M. J. W. & Antoniades, H., Apr 2019, In : Journal of Hepatology. 70, p. E183-E183
Research output: Contribution to journal › Meeting Abstract
Serum bile acid profiles distinguish severe alcoholic hepatitis from decompensated alcohol-related cirrhosis
Tyson, L. D., Atkinson, S., Pechlivanis, A., Holmes, E., Vergis, N., Nathwani, R., Maurice, J., Taylor-Robinson, S., Mullish, B. H., Williams, R., McPhail, M. J. W., Patel, V. & Thursz, M., Apr 2019, In : Journal of Hepatology. 70, p. E108-E108
Research output: Contribution to journal › Meeting Abstract
Hemorrhagic and thrombotic complications in critically patients with cirrhosis
Ow, T-W., Fatourou, E., Rabinowich, L., Roberts, L., Williams, R., Auzinger, G., McPhail, M. J. W., Wendon, J. & Bernal, W., Apr 2019, In : Journal of Hepatology. 70, p. E173-E173
Research output: Contribution to journal › Meeting Abstract
PD-1+monocytes and macrophages contribute to impaired microbial clearance following acute liver failure
Triantafyllou, E., Gudd, C., Nathwani, R., Trovato, F., Possamai, L., Morrison, R., Bernsmeier, C., Patel, V., Khamri, W., Goldin, R., Wendon, J., McPhail, M., Woollard, K., Thursz, M. & Antoniades, C., Apr 2019, In : Journal of Hepatology. 70, p. E430-E431
Research output: Contribution to journal › Meeting Abstract

View all (93) »

Top downloads

Multivariate metabotyping of plasma accurately predicts survival in patients with decompensated cirrhosis.
Research output: Contribution to journal › Article
168
downloads
Update on the management of acute liver failure
Research output: Contribution to journal › Article
55
downloads
Metabolic phenotype of skeletal muscle in early critical illness
Research output: Contribution to journal › Article
48
downloads
High-Speed Quantitative UPLC-MS Analysis of Multiple Amines in Human Plasma and Serum via Precolumn Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate: Application to Acetaminophen-Induced Liver Failure
Research output: Contribution to journal › Article
33
downloads
Improving the Diagnostic Criteria for Primary Liver Graft Nonfunction in Adults Utilizing Standard and Transportable Laboratory Parameters: An Outcome-Based Analysis
Research output: Contribution to journal › Article
16
downloads

View graph of relations

King's College London - Homepage