Dr Mark McPhail
Snr Clinical Lecturer in Experimental Medicine
Contact details:
Postal address:
tbc
James Black Centre
Denmark Hill
James Black Centre
Denmark Hill
United Kingdom
E-mail: mark.mcphail@kcl.ac.uk
ORCID: 0000-0001-5449-2424
Scopus Author ID: 12782644400
Department
Research interests
Mark McPhail is a Senior Lecturer and Consultant in Liver Critical Care and Hepatology in the Institute of Liver Studies, King's College London and Department of Hepatology at Imperial College. His main research interests are in outcome prediction, metabolism and immunity in liver failure syndromes. He is also working on novel methods to diagnose and monitor hepatic encephalopathy and sepsis.
He also holds a PhD in Molecular Physics from the University of Strathclyde. During his doctorate he collaborated with the NASA Jet Propulsion Laboratory, Pasadena and the University of Bologna on modelling rotation and vibration of atmospheric molecules involved in ozone depletion and global warming.
While retraining in medicine following his PhD he maintained an interest in teaching physics as an Associate Lecturer with the Open University. He continues to develop an interest in statistics and has published widely using multivariate methods.
His present focus is on using metabolic profiling to improve prognostication and find novel pathways for metabolic modulation of innate immune responses through the action of lipids on CD14+ monocytes in patients with acute and acute-on-chronic liver failure.
Dysregulation of the LPC-ATX-LPA axis in ACLF is associated with mortality and systemic inflammation via LPA-dependent monocyte activation
Trovato, F. M., Zia, R., Napoli, S., Wolfer, K., Huang, X., Morgan, P. E., Husbyn, H., Elgosbi, M., Lucangeli, M., Miquel, R., Wilson, I., Heaton, N., Heneghan, M., Auzinger, G., Antoniades, C. G., Wendon, J. A., Patel, V. C., Coen, M., Triantafyllou, E. & McPhail, M. J., 28 Apr 2021, In: Hepatology.Research output: Contribution to journal › Article › peer-review
SARS-CoV-2 RNAemia and proteomic biomarker trajectory inform prognostication in COVID-19 patients admitted to intensive care
Gutmann, C., Takov, K., Burnap, S., Singh, B., Theofilatos, K., Reed, E., Hasman, M., Nabeebaccus, A., Fish, M., McPhail, M., O'Gallagher, K., Rienks, M., Yin, X., Auzinger, G., Napoli, S., Mujib, S., Trovato, F., Sanderson, B., Merrick, B., Niazi, U. & 12 others, , 28 Apr 2021, (Accepted/In press) In: Nature Communications.Research output: Contribution to journal › Article › peer-review
Mitochondrial dysfunction as a mechanistic biomarker in patients with non-alcoholic fatty liver disease (NAFLD)
Ajaz, S., McPhail, M. J., Gnudi, L., Trovato, F. M., Mujib, S., Napoli, S., Carey, I. & Agarwal, K., Mar 2021, In: MITOCHONDRION. 57, p. 119-130 12 p.Research output: Contribution to journal › Article › peer-review
Patterns and prediction of liver injury with persistent cholestasis in survivors of severe SARS-CoV-2 infection
Nayagam, J. S., Jeyaraj, R., Mitchell, T., Walder, D. P., Al-Agil, M., Shek, A., Barker, R., Teo, J., Maharaj, R., Agarwal, K., Vlachos, S., Joshi, D. & McPhail, M. JW., 2021, (Accepted/In press) In: Journal of Infection.Research output: Contribution to journal › Letter › peer-review
Top downloads
- 270
Multivariate metabotyping of plasma accurately predicts survival in patients with decompensated cirrhosis.
Research output: Contribution to journal › Article › peer-review
downloads - 236
Update on the management of acute liver failure
Research output: Contribution to journal › Article › peer-review
downloads - 194
Metabolic phenotype of skeletal muscle in early critical illness
Research output: Contribution to journal › Article › peer-review
downloads - 130
High-Speed Quantitative UPLC-MS Analysis of Multiple Amines in Human Plasma and Serum via Precolumn Derivatization with 6-Aminoquinolyl-N-hydroxysuccinimidyl Carbamate: Application to Acetaminophen-Induced Liver Failure
Research output: Contribution to journal › Article › peer-review
downloads - 125
Improving the Diagnostic Criteria for Primary Liver Graft Nonfunction in Adults Utilizing Standard and Transportable Laboratory Parameters: An Outcome-Based Analysis
Research output: Contribution to journal › Article › peer-review
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